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BMC Anesthesiology

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Open Access 01-12-2024 | Esketamine | Research

Esketamine use is associated with shortened postoperative hospital stay in patients after knee arthroscopic surgery: a propensity score–matched cohort study

Authors: Jing Liu, Hong Han, Shangze Yang, Xiaoxuan Zhan, Bingbing Cao, Yue Peng

Published in: BMC Anesthesiology | Issue 1/2024

Abstract

Background

Previous studies have examined anesthetics to improve postoperative prognosis after knee arthroscopic surgery. However, it is currently unknown whether perioperative anesthetics can influence postoperative hospital stay. We investigated the impact of esketamine after knee arthroscopic surgery on post-operative length of stay, fever and surgical site infection.

Methods

This study included 455 patients who underwent knee surgery between January2020 and August 2021at a tertiary hospital in China. Patient characteristics, preoperative laboratory values, intra-operative anesthetic data, and postoperative outcomes were collected. Univariate and multivariate logistic regression analyses with or without propensity score matching were performed to identify factors related to post-operative discharge within 3 days(PD3).

Results

A total of 297 cases met our inclusion criteria. The mean age of patients was 42 ± 14 years, mean body mass index, 24.1 ± 3.5 kg/m², 157(53%) patients were male. Meniscus-related procedures accounted for the most part of all the procedures with a percentage of 40.4%, followed by combined procedures of 35.4%. After we adjusted for demographic and intraoperative characteristics with propensity score matching, esketamine use was significantly associated with PD3 with the highest odds ratio of 2.28 (95% confidence interval (CI): 1.18–4.41, p = 0.014).

Conclusion

Esketamine use was associated with PD3 in patients underwent knee arthroscopic surgery. The findings of this study will be useful to anesthesiologists in making informed decisions regarding the choice of anesthetics for knee joint diseases.

Trial registration

This study was approved by the Ethics Committee (Approval No.:2023-041-01) of the Eighth Affiliated Hospital, Sun Yat-sen University and retrospectively registered.

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Title: Esketamine use is associated with shortened postoperative hospital stay in patients after knee arthroscopic surgery: a propensity score–matched cohort study
Authors: Jing Liu
Hong Han
Shangze Yang
Xiaoxuan Zhan
Bingbing Cao
Yue Peng
Publication date: 01-12-2024
Publisher: BioMed Central
Keywords: Esketamine
Esketamin
Arthroscopy of the Knee Joint
Anesthetics
Anesthetics
Published in: BMC Anesthesiology / Issue 1/2024
Electronic ISSN: 1471-2253
DOI: https://doi.org/10.1186/s12871-023-02376-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Esketamine use is associated with shortened postoperative hospital stay in patients after knee arthroscopic surgery: a propensity score–matched cohort study

Abstract

Background

Methods

Results

Conclusion

Trial registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

Trial registration

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