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Journal of Mammary Gland Biology and Neoplasia

Published in:

01-06-2010

Epithelial-to-Mesenchymal Transitions and Circulating Tumor Cells

Authors: Arnaud Bonnomet, Anne Brysse, Anthony Tachsidis, Mark Waltham, Erik W. Thompson, Myriam Polette, Christine Gilles

Published in: Journal of Mammary Gland Biology and Neoplasia | Issue 2/2010

Abstract

Epithelial-to-mesenchymal transition (EMT) phenomena endow epithelial cells with enhanced migratory and invasive potential, and as such, have been implicated in many physiological and pathological processes requiring cell migration/invasion. Although their involvement in the metastatic cascade is still a subject of debate, data are accumulating to demonstrate the existence of EMT phenotypes in primary human tumors, describe enhanced metastatic potential of EMT derivatives in animal models, and report EMT attributes in circulating tumor cells (CTCs). The relationships between EMT and CTCs remain largely unexplored, and we review here in vitro and in vivo data supporting a putative role of EMT processes in CTC generation and survival.

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Title: Epithelial-to-Mesenchymal Transitions and Circulating Tumor Cells
Authors: Arnaud Bonnomet
Anne Brysse
Anthony Tachsidis
Mark Waltham
Erik W. Thompson
Myriam Polette
Christine Gilles
Publication date: 01-06-2010
Publisher: Springer US
Published in: Journal of Mammary Gland Biology and Neoplasia / Issue 2/2010
Print ISSN: 1083-3021
Electronic ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-010-9174-0

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Epithelial-Mesenchymal Transition (EMT) in Tumor-Initiating Cells and Its Clinical Implications in Breast Cancer

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