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International Journal of Colorectal Disease

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01-03-2020 | Enterostomy | Original Article

The C-reactive protein to albumin ratio predicts postoperative complications in oldest-old patients with colorectal cancer

Authors: Shintaro Hashimoto, Tetsuro Tominaga, Takashi Nonaka, Kiyoaki Hamada, Masato Araki, Hiroaki Takeshita, Hidetoshi Fukuoka, Hideo Wada, Kazuo To, Hideaki Komatsu, Kenji Tanaka, Terumitsu Sawai, Takeshi Nagayasu

Published in: International Journal of Colorectal Disease | Issue 3/2020

Abstract

Purpose

The C-reactive protein to albumin ratio (CAR) is a simple and useful score for predicting the outcomes of patients with various cancers. The aim of this study was to evaluate the CAR and short-term outcomes in oldest-old patients with colorectal cancer.

Methods

A total of 126 patients aged 85 years and older with colorectal cancer who underwent resection for primary colon cancer from April 2015 to December 2018 were included. The preoperative cutoff value of the CAR for predicting postoperative complications was 0.19 on receiver operating characteristic curve analysis. Clinical characteristics and inflammation-based scores were compared between patients with a high CAR (CAR ≥ 0.19, n = 44) and a low CAR (CAR < 0.19, n = 82).

Results

A high preoperative CAR level (≥ 0.19) was significantly associated with stoma construction (p = 0.004), blood loss (p = 0.003), postoperative complications (p = 0.016), and systemic inflammation marker levels, including a low neutrophil to lymphocyte ratio (p = 0.006), a low platelet to lymphocyte ratio (p = 0.005), a low prognostic nutritional index (p < 0.001), and a high modified Glasgow prognostic score (p < 0.001). On univariate and multivariate analyses, only the CAR was an independent predictor of postoperative complications (HR 2.864, p = 0.029).

Conclusions

A high CAR was significantly associated with postoperative complications for oldest-old patients with colorectal cancer.

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Title: The C-reactive protein to albumin ratio predicts postoperative complications in oldest-old patients with colorectal cancer
Authors: Shintaro Hashimoto
Tetsuro Tominaga
Takashi Nonaka
Kiyoaki Hamada
Masato Araki
Hiroaki Takeshita
Hidetoshi Fukuoka
Hideo Wada
Kazuo To
Hideaki Komatsu
Kenji Tanaka
Terumitsu Sawai
Takeshi Nagayasu
Publication date: 01-03-2020
Publisher: Springer Berlin Heidelberg
Keywords: Enterostomy
Enterostomy
Colorectal Cancer
Colorectal Cancer
Published in: International Journal of Colorectal Disease / Issue 3/2020
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-019-03491-z

At a glance: The STEP trials

Springer Medicine

The C-reactive protein to albumin ratio predicts postoperative complications in oldest-old patients with colorectal cancer

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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