Published in:
24-08-2023 | Encephalopathy | Scientific Letter
Plasmapheresis in Acute Necrotizing Encephalopathy of Childhood Secondary to Dengue
Authors:
Jerin C. Sekhar, B. Rajitha, Chethan Nagaraju, Shagun Singh, Aarushi Sahni, Divjot Singh Lamba, Rekha Hans, Sameer Vyas, Suresh Kumar Angurana
Published in:
Indian Journal of Pediatrics
|
Issue 2/2024
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Excerpt
To the Editor: Acute necrotizing encephalopathy of childhood (ANEC) is a severe encephalopathy primarily affecting young children [
1]. It is commonly precipitated by viruses [influenza, parainfluenza, dengue, human herpes virus 6 and 7, herpes simplex virus (HSV), varicella, enterovirus, rotavirus, rubella, coxsackie A9, measles, and SARS-CoV-2] and pathogenesis involves direct viral and immune mediated injury, or cytokine storm resulting in brain injury [
1‐
3]. Neuroradiology shows symmetrical involvement of thalamus, internal capsule, putamen, cerebellum, and brainstem; and cerebrospinal fluid (CSF) analysis shows elevated protein with no pleocytosis [
1‐
3]. Treatment includes antivirals, steroids, IVIG, and plasmapheresis. Despite rigorous management, outcome is usually poor [
1‐
4]. …
