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Published in:

01-09-2014

Emerging technology: applications of Raman spectroscopy for prostate cancer

Authors: Rachel E. Kast, Stephanie C. Tucker, Kevin Killian, Micaela Trexler, Kenneth V. Honn, Gregory W. Auner

Published in: Cancer and Metastasis Reviews | Issue 2-3/2014

Abstract

There is a need in prostate cancer diagnostics and research for a label-free imaging methodology that is nondestructive, rapid, objective, and uninfluenced by water. Raman spectroscopy provides a molecular signature, which can be scaled from micron-level regions of interest in cells to macroscopic areas of tissue. It can be used for applications ranging from in vivo or in vitro diagnostics to basic science laboratory testing. This work describes the fundamentals of Raman spectroscopy and complementary techniques including surface enhanced Raman scattering, resonance Raman spectroscopy, coherent anti-Stokes Raman spectroscopy, confocal Raman spectroscopy, stimulated Raman scattering, and spatially offset Raman spectroscopy. Clinical applications of Raman spectroscopy to prostate cancer will be discussed, including screening, biopsy, margin assessment, and monitoring of treatment efficacy. Laboratory applications including cell identification, culture monitoring, therapeutics development, and live imaging of cellular processes are discussed. Potential future avenues of research are described, with emphasis on multiplexing Raman spectroscopy with other modalities.

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Title: Emerging technology: applications of Raman spectroscopy for prostate cancer
Authors: Rachel E. Kast
Stephanie C. Tucker
Kevin Killian
Micaela Trexler
Kenneth V. Honn
Gregory W. Auner
Publication date: 01-09-2014
Publisher: Springer US
Published in: Cancer and Metastasis Reviews / Issue 2-3/2014
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-013-9489-6

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