Skip to main content
Top
Published in: Diabetologia 11/2006

01-11-2006 | For Debate

Embryonic stem cell-based diabetes therapy—a long road to travel

Author: P. Serup

Published in: Diabetologia | Issue 11/2006

Login to get access

Excerpt

Embryonic stem (ES) cells have been widely heralded as a source of differentiated cells to be used in cell-replacement therapy (CRT), which has potential as a treatment for a number of degenerative diseases, including Parkinson’s disease, Alzheimer’s disease and diabetes [13]. The potential impact of CRT on human life is huge. Not only will healthcare systems be transformed, but a number of societal issues will emerge if cell-based therapy is fully developed. There are, however, widely diverging views as to when we can expect to see cell-based treatment for major diseases (see e.g. [4] in this issue), and over-optimistic views have been expressed in the press and elsewhere. Here I present a more pessimistic view on the amount of time that will be needed to develop CRT for the treatment of diabetes. …
Literature
1.
go back to reference Doss MX, Koehler CI, Gissel C, Hescheler J, Sachinidis A (2004) Embryonic stem cells: a promising tool for cell replacement therapy. J Cell Mol Med 8:465–473PubMed Doss MX, Koehler CI, Gissel C, Hescheler J, Sachinidis A (2004) Embryonic stem cells: a promising tool for cell replacement therapy. J Cell Mol Med 8:465–473PubMed
2.
go back to reference Keller G (2005) Embryonic stem cell differentiation: emergence of a new era in biology and medicine. Genes Dev 19:1129–1155PubMedCrossRef Keller G (2005) Embryonic stem cell differentiation: emergence of a new era in biology and medicine. Genes Dev 19:1129–1155PubMedCrossRef
3.
4.
go back to reference Rolletschek A, Kania G, Wobus AM (2006) Generation of pancreatic insulin-producing cells from embryonic stem cells— ‘Proof of principle’, but questions still unanswered. Diabetologia DOI 10.1007/s00125-006-0441-y Rolletschek A, Kania G, Wobus AM (2006) Generation of pancreatic insulin-producing cells from embryonic stem cells— ‘Proof of principle’, but questions still unanswered. Diabetologia DOI 10.​1007/​s00125-006-0441-y
5.
go back to reference Shapiro AM, Lakey JR, Ryan EA et al (2000) Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 343:230–238PubMedCrossRef Shapiro AM, Lakey JR, Ryan EA et al (2000) Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 343:230–238PubMedCrossRef
6.
go back to reference Nanji SA, Shapiro AM (2004) Islet transplantation in patients with diabetes mellitus: choice of immunosuppression. BioDrugs 18:315–328PubMedCrossRef Nanji SA, Shapiro AM (2004) Islet transplantation in patients with diabetes mellitus: choice of immunosuppression. BioDrugs 18:315–328PubMedCrossRef
7.
go back to reference Steil GM, Rebrin K (2005) Closed-loop insulin delivery—what lies between where we are and where we are going? Expert Opin Drug Deliv 2:353–362PubMedCrossRef Steil GM, Rebrin K (2005) Closed-loop insulin delivery—what lies between where we are and where we are going? Expert Opin Drug Deliv 2:353–362PubMedCrossRef
8.
go back to reference Zwillich T (2000) Diabetes research. Islet transplants not yet ready for prime time. Science 289:531–533PubMedCrossRef Zwillich T (2000) Diabetes research. Islet transplants not yet ready for prime time. Science 289:531–533PubMedCrossRef
9.
go back to reference Soria B, Roche E, Berna G, Leon-Quinto T, Reig JA, Martin F (2000) Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 49:157–162PubMed Soria B, Roche E, Berna G, Leon-Quinto T, Reig JA, Martin F (2000) Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 49:157–162PubMed
10.
go back to reference Vaca P, Martin F, Vegara-Meseguer J, Rovira J, Berna G, Soria B (2005) Induction of differentiation of embryonic stem cells into insulin secreting cells by fetal soluble factors. Stem Cells 18:18 Vaca P, Martin F, Vegara-Meseguer J, Rovira J, Berna G, Soria B (2005) Induction of differentiation of embryonic stem cells into insulin secreting cells by fetal soluble factors. Stem Cells 18:18
11.
go back to reference Kahan BW, Jacobson LM, Hullett DA et al (2003) Pancreatic precursors and differentiated islet cell types from murine embryonic stem cells: an in vitro model to study islet differentiation. Diabetes 52:2016–2024PubMed Kahan BW, Jacobson LM, Hullett DA et al (2003) Pancreatic precursors and differentiated islet cell types from murine embryonic stem cells: an in vitro model to study islet differentiation. Diabetes 52:2016–2024PubMed
12.
go back to reference Assady S, Maor G, Amit M, Itskovitz-Eldor J, Skorecki KL, Tzukerman M (2001) Insulin production by human embryonic stem cells. Diabetes 50:1691–1697PubMed Assady S, Maor G, Amit M, Itskovitz-Eldor J, Skorecki KL, Tzukerman M (2001) Insulin production by human embryonic stem cells. Diabetes 50:1691–1697PubMed
13.
go back to reference Lumelsky N, Blondel O, Laeng P, Velasco I, Ravin R, McKay R (2001) Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 292:1389–1394PubMedCrossRef Lumelsky N, Blondel O, Laeng P, Velasco I, Ravin R, McKay R (2001) Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 292:1389–1394PubMedCrossRef
14.
go back to reference Blyszczuk P, Czyz J, Kania G et al (2003) Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells. Proc Natl Acad Sci USA 100:998–1003PubMedCrossRef Blyszczuk P, Czyz J, Kania G et al (2003) Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells. Proc Natl Acad Sci USA 100:998–1003PubMedCrossRef
15.
go back to reference Hori Y, Rulifson IC, Tsai BC, Heit JJ, Cahoy JD, Kim SK (2002) Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc Natl Acad Sci USA 99:16105–16110PubMedCrossRef Hori Y, Rulifson IC, Tsai BC, Heit JJ, Cahoy JD, Kim SK (2002) Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc Natl Acad Sci USA 99:16105–16110PubMedCrossRef
16.
go back to reference Kim SK, Hebrok M (2001) Intercellular signals regulating pancreas development and function. Genes Dev 15:111–127PubMedCrossRef Kim SK, Hebrok M (2001) Intercellular signals regulating pancreas development and function. Genes Dev 15:111–127PubMedCrossRef
17.
go back to reference Edlund H (2001) Developmental biology of the pancreas. Diabetes 50 [Suppl 1]:S5–S9PubMed Edlund H (2001) Developmental biology of the pancreas. Diabetes 50 [Suppl 1]:S5–S9PubMed
18.
go back to reference Smit AB, Vreugdenhil E, Ebberink RH, Geraerts WP, Klootwijk J, Joosse J (1988) Growth-controlling molluscan neurons produce the precursor of an insulin-related peptide. Nature 331:535–538PubMedCrossRef Smit AB, Vreugdenhil E, Ebberink RH, Geraerts WP, Klootwijk J, Joosse J (1988) Growth-controlling molluscan neurons produce the precursor of an insulin-related peptide. Nature 331:535–538PubMedCrossRef
19.
go back to reference Brogiolo W, Stocker H, Ikeya T, Rintelen F, Fernandez R, Hafen E (2001) An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr Biol 11:213–221PubMedCrossRef Brogiolo W, Stocker H, Ikeya T, Rintelen F, Fernandez R, Hafen E (2001) An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr Biol 11:213–221PubMedCrossRef
20.
go back to reference Rulifson EJ, Kim SK, Nusse R (2002) Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science 296:1118–1120PubMedCrossRef Rulifson EJ, Kim SK, Nusse R (2002) Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science 296:1118–1120PubMedCrossRef
21.
go back to reference Clarke DW, Mudd L, Boyd FT Jr, Fields M, Raizada MK (1986) Insulin is released from rat brain neuronal cells in culture. J Neurochem 47:831–836PubMedCrossRef Clarke DW, Mudd L, Boyd FT Jr, Fields M, Raizada MK (1986) Insulin is released from rat brain neuronal cells in culture. J Neurochem 47:831–836PubMedCrossRef
22.
go back to reference Lee SH, Lumelsky N, Studer L, Auerbach JM, McKay RD (2000) Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat Biotechnol 18:675–679PubMedCrossRef Lee SH, Lumelsky N, Studer L, Auerbach JM, McKay RD (2000) Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat Biotechnol 18:675–679PubMedCrossRef
23.
go back to reference Rajagopal J, Anderson WJ, Kume S, Martinez OI, Melton DA (2003) Insulin staining of ES cell progeny from insulin uptake. Science 299:363PubMed Rajagopal J, Anderson WJ, Kume S, Martinez OI, Melton DA (2003) Insulin staining of ES cell progeny from insulin uptake. Science 299:363PubMed
24.
go back to reference Sipione S, Eshpeter A, Lyon JG, Korbutt GS, Bleackley RC (2004) Insulin expressing cells from differentiated embryonic stem cells are not beta cells. Diabetologia 47:499–508PubMedCrossRef Sipione S, Eshpeter A, Lyon JG, Korbutt GS, Bleackley RC (2004) Insulin expressing cells from differentiated embryonic stem cells are not beta cells. Diabetologia 47:499–508PubMedCrossRef
25.
go back to reference Hansson M, Tonning A, Frandsen U et al (2004) Artifactual insulin release from differentiated embryonic stem cells. Diabetes 53:2603–2609PubMed Hansson M, Tonning A, Frandsen U et al (2004) Artifactual insulin release from differentiated embryonic stem cells. Diabetes 53:2603–2609PubMed
26.
go back to reference Kubo A, Shinozaki K, Shannon JM et al (2004) Development of definitive endoderm from embryonic stem cells in culture. Development 131:1651–1662PubMedCrossRef Kubo A, Shinozaki K, Shannon JM et al (2004) Development of definitive endoderm from embryonic stem cells in culture. Development 131:1651–1662PubMedCrossRef
27.
go back to reference Tada S, Era T, Furusawa C et al (2005) Characterization of mesendoderm: a diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture. Development 132:4363–4374PubMedCrossRef Tada S, Era T, Furusawa C et al (2005) Characterization of mesendoderm: a diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture. Development 132:4363–4374PubMedCrossRef
28.
go back to reference Yasunaga M, Tada S, Torikai-Nishikawa S et al (2005) Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells. Nat Biotechnol 23:1542–1550PubMedCrossRef Yasunaga M, Tada S, Torikai-Nishikawa S et al (2005) Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells. Nat Biotechnol 23:1542–1550PubMedCrossRef
29.
go back to reference D’Amour KA, Agulnick AD, Eliazer S, Kelly OG, Kroon E, Baetge EE (2005) Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol 23:1534–1541PubMedCrossRef D’Amour KA, Agulnick AD, Eliazer S, Kelly OG, Kroon E, Baetge EE (2005) Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol 23:1534–1541PubMedCrossRef
30.
go back to reference Tam PP, Kanai-Azuma M, Kanai Y (2003) Early endoderm development in vertebrates: lineage differentiation and morphogenetic function. Curr Opin Genet Dev 13:393–400PubMedCrossRef Tam PP, Kanai-Azuma M, Kanai Y (2003) Early endoderm development in vertebrates: lineage differentiation and morphogenetic function. Curr Opin Genet Dev 13:393–400PubMedCrossRef
31.
go back to reference Brolen GK, Heins N, Edsbagge J, Semb H (2005) Signals from the embryonic mouse pancreas induce differentiation of human embryonic stem cells into insulin-producing beta-cell-like cells. Diabetes 54:2867–2874PubMed Brolen GK, Heins N, Edsbagge J, Semb H (2005) Signals from the embryonic mouse pancreas induce differentiation of human embryonic stem cells into insulin-producing beta-cell-like cells. Diabetes 54:2867–2874PubMed
Metadata
Title
Embryonic stem cell-based diabetes therapy—a long road to travel
Author
P. Serup
Publication date
01-11-2006
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 11/2006
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-006-0434-x

Other articles of this Issue 11/2006

Diabetologia 11/2006 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.