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Diabetologia
Published in: Diabetologia 11/2006

01-11-2006 | Research Letter

Low cerebrospinal fluid insulin levels in obese humans

Authors: W. Kern, C. Benedict, B. Schultes, F. Plohr, A. Moser, J. Born, H. L. Fehm, M. Hallschmid

Published in: Diabetologia | Issue 11/2006

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Excerpt

To the Editor: …
Literature
1.
Wallum BJ, Porte D Jr, Figlewicz DP, Jacobson L, Dorsa D (1987) Cerebrospinal fluid insulin levels increase during intravenous insulin infusion in man. J Clin Endocrinol Metab 64:190–194PubMedCrossRef
2.
Obici S, Feng Z, Karkanias G, Baskin DG, Rossetti L (2002) Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat Neurosci 5:566–572PubMedCrossRef
3.
Obici S, Zhang BB, Karkanias G, Rossetti L (2002) Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med 8:1376–1382PubMedCrossRef
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Woods SC, Seeley RJ, Baskin DG, Schwartz MW (2003) Insulin and the blood–brain barrier. Curr Pharm Res 9:795–800CrossRef
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Schwartz MW, Figlewicz DP, Kahn SE, Baskin DG, Greenwood MR, Porte D Jr (1990) Insulin binding to brain capillaries is reduced in genetically obese, hyperinsulinemic Zucker rats. Peptides 11:467–472PubMedCrossRef
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Baura GD, Foster DM, Kaiyala K, Porte D Jr, Kahn SE, Schwartz MW (1996) Insulin transport from plasma into the central nervous system is inhibited by dexamethasone in dogs. Diabetes 45:86–90PubMed
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Caro JF, Kolaczynski JW, Nyce MR et al (1996) Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistence. Lancet 348:159–161PubMedCrossRef
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Schubert M, Gautam D, Surjo D et al (2004) Role for neuronal insulin resistance in neurodegenerative diseases. Proc Natl Acad Sci USA 101:3100–3105PubMedCrossRef
Metadata
Title
Low cerebrospinal fluid insulin levels in obese humans
Authors
W. Kern
C. Benedict
B. Schultes
F. Plohr
A. Moser
J. Born
H. L. Fehm
M. Hallschmid
Publication date
01-11-2006
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 11/2006
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-006-0409-y

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Obesity Clinical Trial Summary

At a glance: The STEP trials

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A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

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