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01-04-2018 | Clinical trial

Effects of physical exercise on markers of inflammation in breast cancer patients during adjuvant chemotherapy

Authors: Jonna K. van Vulpen, Martina E. Schmidt, Miranda J. Velthuis, Joachim Wiskemann, Andreas Schneeweiss, Roel C. H. Vermeulen, Nina Habermann, Cornelia M. Ulrich, Petra H. M. Peeters, Elsken van der Wall, Anne M. May, Karen Steindorf

Published in: Breast Cancer Research and Treatment | Issue 2/2018

Abstract

Purpose

Exercise has been shown to reduce fatigue during cancer treatment. Hypothesized mechanisms include inflammatory pathways. Therefore, we investigated effects of exercise on markers of inflammation in breast cancer patients during adjuvant chemotherapy.

Methods

We pooled data from two randomized controlled exercise intervention trials with breast cancer patients during adjuvant chemotherapy (n = 130), which had previously shown beneficial effects of exercise on fatigue. Exercise comprised a 12-week resistance training (BEATE study) or an 18-week combined resistance and aerobic training (PACT study). Serum IL-6, IL-1ra, and the IL-6/IL-1ra ratio were quantified at baseline, mid-intervention, post-intervention, and 6–9 months post-baseline.

Results

Mixed effect models showed significant increases in IL-6 and IL-6/IL-1ra ratio during chemotherapy and decreases afterwards. Differences between exercise and control group were not significant at any time point. Changes in total cancer-related fatigue were significantly correlated with changes in IL-6/IL-1ra ratio (partial correlation r = 0.23) and IL-6 (r = 0.21), and changes in physical cancer-related fatigue with changes in IL-6/IL-1ra ratio (r = 0.21).

Conclusions

Changes in fatigue were slightly correlated with changes in inflammatory markers, and there was a strong inflammatory response to adjuvant chemotherapy. The supervised exercise training did not counteract this increase in inflammation, suggesting that beneficial effects of exercise on fatigue during adjuvant chemotherapy for breast cancer are not essentially mediated by IL-6, IL-1ra, or the IL-6/IL-1ra ratio.

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Title: Effects of physical exercise on markers of inflammation in breast cancer patients during adjuvant chemotherapy
Authors: Jonna K. van Vulpen
Martina E. Schmidt
Miranda J. Velthuis
Joachim Wiskemann
Andreas Schneeweiss
Roel C. H. Vermeulen
Nina Habermann
Cornelia M. Ulrich
Petra H. M. Peeters
Elsken van der Wall
Anne M. May
Karen Steindorf
Publication date: 01-04-2018
Publisher: Springer US
Published in: Breast Cancer Research and Treatment / Issue 2/2018
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-017-4608-7

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