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Comparative Hepatology
Published in: Comparative Hepatology 1/2004

Open Access 01-01-2004 | Proceedings

Effects of acetaminophen on hepatic microcirculation in mice

Authors: Yoshiya Ito, Nancy W Machen, Edward R Abril, Robert S McCuskey

Published in: Comparative Hepatology | Special Issue 1/2004

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Excerpt

Acetaminophen (APAP) intoxication from overdosing can result in severe hepatic damage, which is characterized by hemorrhagic centrilobular necrosis and by towering the levels of transaminase. The APAP-induced hepatic necrosis is preceded by centrilobular microvascular congestion thought to be due to collapse of the sinusoidal wall and the infiltration of blood elements into the space of Disse [1]. These findings suggest that, in addition to direct hepatocellular damage, sinusoidal endothelial cells (SECs) participate in liver injury elicited by APAP overdose. As a result, the present study was conducted to examine changes in hepatic microcirculation after APAP administration using in vivo microscopic methods. …
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Smedsr–d B, Pertoft H, Gustafson S, Laurent T: Scavenger functions of the liver endothelial cell. Biochem J. 1990, 266: 313-327.CrossRef
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Laskin DL, Gardner CR, Price VF, Jollow DJ: Modulation of macrophages functioning abrogates the acute hepatotoxicity of acetaminophen. Hepatology. 1995, 21: 1045-1050. 10.1016/0270-9139(95)90253-8.CrossRefPubMed
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Metadata
Title
Effects of acetaminophen on hepatic microcirculation in mice
Authors
Yoshiya Ito
Nancy W Machen
Edward R Abril
Robert S McCuskey
Publication date
01-01-2004
Publisher
BioMed Central
Published in
Comparative Hepatology / Issue Special Issue 1/2004
Electronic ISSN: 1476-5926
DOI
https://doi.org/10.1186/1476-5926-2-S1-S33

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