Published in:
Open Access
01-01-2004 | Proceedings
The regulatory role of prostaglandin E2in liver (patho) physiology is controlled at its site of synthesis and its action on the receptors
Authors:
Peter Dieter, Roland Scheibe, Yefgeniya Bezugla, Egbert Matthé, Sandra Schuch, Lars Treffkorn, Brigitte Bernard, Sabine Kamionka, Angelika Kolada
Published in:
Comparative Hepatology
|
Special Issue 1/2004
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Excerpt
Among the hormone class of the eicosanoids, PGE
2 plays a predominant role in liver (patho) physiology. Liver-specific responses, like regulation of blood glucose homeostasis, sinusoidal blood flow within the liver, properties of the transendothelial barrier within the liver, synthesis and release of important other mediators like cytokines, growth factors or nitric oxide, and liver fibrogenesis have been shown to be mediated or regulated by PGE
2 [
1]. Within the liver, the main producers of PGE
2 are the Kupffer cells. The synthesis of PGE
2 in Kupffer cells is controlled at multiple levels. The action of PGE
2 on its target cells is mediated by 4 classes of PGE
2 receptors (EP1, EP2, EP3, EP4). Each of these receptors converts the information of PGE
2 by different intracellular signal pathways to a specific cellular response [
2]. …
