Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Clinical Oral Investigations
Published in: Clinical Oral Investigations 8/2014

01-11-2014 | Original Article

Effect of nonsurgical periodontal therapy (with or without oral doxycycline delivery) on glycemic status and clinical periodontal parameters in patients with prediabetes: a short-term longitudinal randomized case–control study

Authors: Fawad Javed, Hameeda Bashir Ahmed, Abid Mehmood, Crawford Bain, Georgios E. Romanos

Published in: Clinical Oral Investigations | Issue 8/2014

Login to get access

Abstract

Objective

The aim of the present short-term longitudinal randomized case–control study was to assess the effect of nonsurgical periodontal therapy (NSPT) (with and without oral doxycycline delivery) on glycemic status and clinical periodontal parameters in patients with prediabetes.

Material and methods

Sixty-six patients with prediabetes and periodontal disease were included. Characteristics of the study cohort (age, gender, socioeconomic status [SES] education status, duration of prediabetes, and type of treatment adopted for prediabetes management) were recorded. Patients were randomly divided into two groups (33 patients/group). In group 1, scaling and root planing (SRP) was performed, and in group-2, patients underwent SRP and oral doxycycline (100 mg) administration once daily for 15 days. In each group, the following parameters were investigated at baseline and after 3 months: (a) fasting blood glucose level (FBGL), (b) hemoglobin A1c (HbA1c), and (c) periodontal parameters (plaque index [PI], bleeding on probing [BOP], probing depth [PD], and clinical attachment loss [AL]). Statistical analysis was performed using Student’s t test.

Results

There was no significant difference in age, gender, SES, education status, and duration and treatment of prediabetes among individuals in groups 1 and 2. Three months post-NSPT, FBGL and HbA1c were significantly reduced among patients in group 1 (P < 0.05) and group 2 (P < 0.05) compared to baseline. Three months post-NSPT, PI (P < 0.05), BOP (P < 0.05), and PD (P < 0.05) were significantly reduced among patients in group 1 (P < 0.05) and group 2 (P < 0.05) compared to baseline. There was no difference in clinical AL between the groups after 3 months of NSPT.

Conclusion

NSPT (with and without oral doxycycline delivery) reduces hyperglycemia and periodontal inflammation in patients with prediabetes.
Literature
1.
Taylor GW (2001) Bidirectional interrelationships between diabetes and periodontal diseases: an epidemiologic perspective. Ann Periodontol 6:99–112PubMedCrossRef
2.
Javed F, Sundin U, Altamash M, Klinge B, Engstrom PE (2009) Self-perceived oral health and salivary proteins in children with type 1 diabetes. J Oral Rehabil 36:39–44PubMedCrossRef
3.
Javed F, Nasstrom K, Benchimol D, Altamash M, Klinge B et al (2007) Comparison of periodontal and socioeconomic status between subjects with type 2 diabetes mellitus and non-diabetic controls. J Periodontol 78:2112–2119PubMedCrossRef
4.
Javed F, Tenenbaum HC, Nogueira-Filho G, Nooh N, O’Bello Correa F, et al (2013) Periodontal inflammatory conditions among gutka-chewers and non-chewers with and without prediabetes. J Periodontol 84:1158–1164
5.
Javed F, Al-Askar M, Al-Rasheed A, Babay N, Galindo-Moreno P et al (2012) Comparison of self-perceived oral health, periodontal inflammatory conditions and socioeconomic status in individuals with and without prediabetes. Am J Med Sci 344:100–104PubMedCrossRef
6.
Javed F, Klingspor L, Sundin U, Altamash M, Klinge B et al (2009) Periodontal conditions, oral Candida albicans and salivary proteins in type 2 diabetic subjects with emphasis on gender. BMC Oral Health 9:12PubMedCrossRefPubMedCentral
7.
Javed F, Al-Askar M, Samaranayake LP, Al-Hezaimi K (2013) Periodontal disease in habitual cigarette smokers and nonsmokers with and without prediabetes. Am J Med Sci 345:94–98PubMedCrossRef
8.
Javed F, Thafeed Alghamdi AS, Mikami T, Mehmood A, Ahmed HB et al (2013) Effect of glycemic control on self-perceived oral health, periodontal parameters and alveolar bone loss among patients with prediabetes. J Periodontol. doi:10.​1902/​jop.​2013.​130008
9.
Javed F, Ahmed HB, Saeed A, Mehmood A, Bain C (2013) Whole salivary interleukin-6 and matrix metalloproteinase-8 levels in chronic periodontitis patients with and without prediabetes. J Periodontol. doi:10.​1902/​jop.​2013.​130514
10.
Nishimura F, Iwamoto Y, Mineshiba J, Shimizu A, Soga Y et al (2003) Periodontal disease and diabetes mellitus: the role of tumor necrosis factor-alpha in a 2-way relationship. J Periodontol 74:97–102PubMedCrossRef
11.
Javed F, Al-Askar M, Al-Hezaimi K (2012) Cytokine profile in the gingival crevicular fluid of periodontitis patients with and without type 2 diabetes: a literature review. J Periodontol 83:156–161PubMedCrossRef
12.
Takeda M, Ojima M, Yoshioka H, Inaba H, Kogo M et al (2006) Relationship of serum advanced glycation end products with deterioration of periodontitis in type 2 diabetes patients. J Periodontol 77:15–20PubMedCrossRef
13.
Koromantzos PA, Makrilakis K, Dereka X, Offenbacher S, Katsilambros N et al (2012) Effect of non-surgical periodontal therapy on C-reactive protein, oxidative stress, and matrix metalloproteinase (MMP)-9 and MMP-2 levels in patients with type 2 diabetes: a randomized controlled study. J Periodontol 83:3–10PubMedCrossRef
14.
Ohnishi T, Bandow K, Kakimoto K, Machigashira M, Matsuyama T et al (2009) Oxidative stress causes alveolar bone loss in metabolic syndrome model mice with type 2 diabetes. J Periodontal Res 44:43–51PubMedCrossRef
15.
Costa PP, Trevisan GL, Macedo GO, Palioto DB, Souza SL et al (2010) Salivary interleukin-6, matrix metalloproteinase-8, and osteoprotegerin in patients with periodontitis and diabetes. J Periodontol 81:384–391PubMedCrossRef
16.
Gaikwad SP, Gurav AN, Shete AR, Desarda HM (2013) Effect of scaling and root planing combined with systemic doxycycline therapy on glycemic control in diabetes mellitus subjects with chronic generalized periodontitis: a clinical study. J Periodontal Implant Sci 43:79–86PubMedCrossRefPubMedCentral
17.
Chen L, Luo G, Xuan D, Wei B, Liu F et al (2012) Effects of non-surgical periodontal treatment on clinical response, serum inflammatory parameters, and metabolic control in patients with type 2 diabetes: a randomized study. J Periodontol 83:435–443PubMedCrossRef
18.
Auyeung L, Wang PW, Lin RT, Hsieh CJ, Lee PY et al (2012) Evaluation of periodontal status and effectiveness of non-surgical treatment in patients with type 2 diabetes mellitus in Taiwan for a 1-year period. J Periodontol 83:621–628PubMedCrossRef
19.
Al-Zahrani MS, Bamshmous SO, Alhassani AA, Al-Sherbini MM (2009) Short-term effects of photodynamic therapy on periodontal status and glycemic control of patients with diabetes. J Periodontol 80:1568–1573PubMedCrossRef
20.
Rodrigues DC, Taba MJ, Novaes AB, Souza SL, Grisi MF (2003) Effect of non-surgical periodontal therapy on glycemic control in patients with type 2 diabetes mellitus. J Periodontol 74:1361–1367PubMedCrossRef
21.
Sgolastra F, Severino M, Pietropaoli D, Gatto R, Monaco A (2012) Effectiveness of periodontal treatment to improve metabolic control in patients with chronic periodontitis and type 2 diabetes: a meta-analysis of randomized clinical trials. J Periodontol 84:958–973PubMedCrossRef
22.
Koromantzos PA, Makrilakis K, Dereka X, Katsilambros N, Vrotsos IA et al (2011) A randomized, controlled trial on the effect of non-surgical periodontal therapy in patients with type 2 diabetes. Part I: effect on periodontal status and glycaemic control. J Clin Periodontol 38:142–147PubMedCrossRef
23.
Akalin FA, Baltacioglu E, Sengun D, Hekimoglu S, Taskin M et al (2004) A comparative evaluation of the clinical effects of systemic and local doxycycline in the treatment of chronic periodontitis. J Oral Sci 46:25–35PubMedCrossRef
24.
Smith GT, Greenbaum CJ, Johnson BD, Persson GR (1996) Short-term responses to periodontal therapy in insulin-dependent diabetic patients. J Periodontol 67:794–802PubMedCrossRef
25.
Association AD (2011) Standards of medical care in diabetes—2011. Diabetes Care 34(Suppl 1):S11–S61CrossRef
26.
Ozcelik F, Yiginer O, Arslan E, Serdar MA, Uz O et al (2010) Association between glycemic control and the level of knowledge and disease awareness in type 2 diabetic patients. Pol Arch Med Wewn 120:399–406PubMed
27.
Ainamo J, Bay I (1975) Problems and proposals for recording gingivitis and plaque. Int Dent J 25:229–235PubMed
28.
Muhlemann HR, Son S (1971) Gingival sulcus bleeding—a leading symptom in initial gingivitis. Helv Odontol Acta 15:107–113PubMed
29.
Armitage GC, Svanberg GK, Loe H (1977) Microscopic evaluation of clinical measurements of connective tissue attachment levels. J Clin Periodontol 4:173–190PubMedCrossRef
30.
Genco RJ, Grossi SG, Ho A, Nishimura F, Murayama Y (2005) A proposed model linking inflammation to obesity, diabetes, and periodontal infections. J Periodontol 76:2075–2084PubMedCrossRef
31.
32.
Armitage GC (1999) Development of a classification system for periodontal diseases and conditions. Ann Periodontol 4:1–6PubMedCrossRef
33.
Pontes Andersen CC, Buschard K, Flyvbjerg A, Stoltze K, Holmstrup P (2006) Periodontitis deteriorates metabolic control in type 2 diabetic Goto-Kakizaki rats. J Periodontol 77:350–356PubMedCrossRef
34.
Beck J, Garcia R, Heiss G, Vokonas PS, Offenbacher S (1996) Periodontal disease and cardiovascular disease. J Periodontol 67:1123–1137PubMedCrossRef
35.
Grossi SG (2001) Treatment of periodontal disease and control of diabetes: an assessment of the evidence and need for future research. Ann Periodontol 6:138–145PubMedCrossRef
36.
Page RC (1998) The pathobiology of periodontal diseases may affect systemic diseases: inversion of a paradigm. Ann Periodontol 3:108–120PubMedCrossRef
37.
Loos BG, Craandijk J, Hoek FJ, Wertheim-van Dillen PM, van der Velden U (2000) Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J Periodontol 71:1528–1534PubMedCrossRef
38.
Grossi SG, Skrepcinski FB, DeCaro T, Robertson DC, Ho AW et al (1997) Treatment of periodontal disease in diabetics reduces glycated hemoglobin. J Periodontol 68:713–719PubMedCrossRef
39.
Ryan ME, Ramamurthy NS, Golub LM (1998) Tetracyclines inhibit protein glycation in experimental diabetes. Adv Dent Res 12:152–158PubMedCrossRef
40.
Li C, Ford ES, Zhao G, Mokdad AH (2009) Prevalence of pre-diabetes and its association with clustering of cardiometabolic risk factors and hyperinsulinemia among U.S. adolescents: National Health and Nutrition Examination Survey 2005–2006. Diabetes Care 32:342–347PubMedCrossRefPubMedCentral
41.
Viswanathan V, Kumpatla S, Aravindalochanan V, Rajan R, Chinnasamy C et al (2012) Prevalence of diabetes and pre-diabetes and associated risk factors among tuberculosis patients in India. PLoS One 7:e41367PubMedCrossRefPubMedCentral
Metadata
Title
Effect of nonsurgical periodontal therapy (with or without oral doxycycline delivery) on glycemic status and clinical periodontal parameters in patients with prediabetes: a short-term longitudinal randomized case–control study
Authors
Fawad Javed
Hameeda Bashir Ahmed
Abid Mehmood
Crawford Bain
Georgios E. Romanos
Publication date
01-11-2014
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 8/2014
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-014-1185-6

Other articles of this Issue 8/2014

Clinical Oral Investigations 8/2014 Go to the issue

Original Article

Gene expression profile of compressed primary human cementoblasts before and after IL-1β stimulation

Original Article

Oxidative stress and recurrent aphthous stomatitis

Original Article

The osteoblastic differentiation ability of human dedifferentiated fat cells is higher than that of adipose stem cells from the buccal fat pad

Original Article

Retention and surface changes of zirconia primary crowns with secondary crowns of different materials

Original Article

Evaluation of light-touch sensation in the buccal mucosa of leprosy patients

Original Article

Effect of selective enamel etching on clinical performance of CAD/CAM partial ceramic crowns luted with a self-adhesive resin cement