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Clinical Oral Investigations
Published in: Clinical Oral Investigations 8/2014

01-11-2014 | Original Article

Oxidative stress and recurrent aphthous stomatitis

Authors: Jose Bagan, Guillermo Saez, Carmen Tormos, Carmen Gavalda, Jose M. Sanchis, Leticia Bagan, Crispian Scully

Published in: Clinical Oral Investigations | Issue 8/2014

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Abstract

Objectives

This study analyzed the oxidative stress status in patients with recurrent aphthous stomatitis (RAS) in the presence and absence of active ulceration.

Material and methods

Oxidative stress was analyzed in peripheral mononuclear cells of 28 RAS patients with active ulceration and 29 controls. A further blood sample was collected from nine subjects randomly selected from the 28 RAS cases, during the period in which the patients did not have active oral ulceration. The reduced glutathione (GSH), malondialdehyde (MDA), and oxidized glutathione (GSSG) levels were measured in these samples.

Results

The mean MDA and GSSG levels were significantly higher in patients with active RAS than in the controls, while GSH was lower in the RAS group (p < 0.01). There was a nonsignificant tendency toward higher MDA and GSSG levels in patients with major RAS compared with minor RAS. On comparing the serum findings in the nine RAS patients in the presence and absence of lesions, the presence of ulceration was associated with even higher MDA and GSSG levels and lower GSH concentrations (p < 0.05)

Conclusions

Oxidative stress was detected in our RAS patients.
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Metadata
Title
Oxidative stress and recurrent aphthous stomatitis
Authors
Jose Bagan
Guillermo Saez
Carmen Tormos
Carmen Gavalda
Jose M. Sanchis
Leticia Bagan
Crispian Scully
Publication date
01-11-2014
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 8/2014
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-013-1181-2

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