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Journal of the International AIDS Society
Published in: Journal of the International AIDS Society 4/2010

Open Access 01-12-2010 | Poster presentation

Effect of intrinsic and extrinsic factors on the pharmacokinetics of TMC278 in antiretroviral-naïve, HIV-1-infected patients in ECHO and THRIVE

Authors: HM Crauwels, E van Schaick, RPG van Heeswijk, S Vanveggel, K Boven, P Vis

Published in: Journal of the International AIDS Society | Special Issue 4/2010

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Excerpt

The current analysis examined the pharmacokinetics of the next-generation investigational NNRTI, TMC278, in the pooled double-blind Phase III trials ECHO (NCT00540449) and THRIVE (NCT00543725) in ARV-naïve, HIV-1-infected adults [1] and explored the influence of intrinsic and extrinsic factors on the pharmacokinetic parameters. …
Literature
1.
Cohen C, Molina JM, Cahn P, et al: Pooled week 48 efficacy and safety results from ECHO and THRIVE, two double-blind, randomised, Phase III trials comparing TMC278 versus efavirenz in treatment-naïve, HIV-1-infected patients. 18th International AIDS Conference, Vienna, Austria. 2010, Abstract THLBB206
Metadata
Title
Effect of intrinsic and extrinsic factors on the pharmacokinetics of TMC278 in antiretroviral-naïve, HIV-1-infected patients in ECHO and THRIVE
Authors
HM Crauwels
E van Schaick
RPG van Heeswijk
S Vanveggel
K Boven
P Vis
Publication date
01-12-2010
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1758-2652-13-S4-P186

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