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BMC Cardiovascular Disorders

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Open Access 01-12-2024 | ECMO | Research

Early changes in cardiac troponin T and NT-proBNP levels in neonates receiving ECMO support: a single-center experience

Authors: Wen-Peng Xie, Yi-Nan Liu, Ya-Ting Zeng, Yi-Rong Zheng, Qiang Chen

Published in: BMC Cardiovascular Disorders | Issue 1/2024

Abstract

Objective

This study aimed to examine the changes in absolute value and decline rate of early serum cardiac troponin T (cTnT) and N-terminal pro b-type natriuretic peptide (NT-proBNP) in neonates who received veno-arterial (V-A) extracorporeal membrane oxygenation (ECMO) support therapy within the first week of life.

Methods

We retrospectively collected clinical data and laboratory test results of 18 neonates who underwent V-A ECMO support within one week of birth, from July 2021 to June 2023, using the electronic medical record system. These patients were categorized into survival and death groups. Comparative analyses of the absolute values and decline rates of cTnT and NT-proBNP were made between the groups at baseline, and at 24, 48, and 72 h post-ECMO initiation.

Results

Out of the 18 neonates, 12 survived (survival rate: 66.7%), while 6 succumbed. The survival group exhibited significantly lower absolute values of cTnT and NT-proBNP than the death group, and their decline rates were significantly higher. Notably, all neonates without an early decline in cTnT and NT-proBNP levels were in the death group.

Conclusion

The early changes in the absolute value and decline rate of serum cTnT and NT-proBNP in neonates undergoing V-A ECMO may serve as predictors of their prognosis.

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Title: Early changes in cardiac troponin T and NT-proBNP levels in neonates receiving ECMO support: a single-center experience
Authors: Wen-Peng Xie
Yi-Nan Liu
Ya-Ting Zeng
Yi-Rong Zheng
Qiang Chen
Publication date: 01-12-2024
Publisher: BioMed Central
Keywords: ECMO
ECMO
Acute Respiratory Distress-Syndrome
Published in: BMC Cardiovascular Disorders / Issue 1/2024
Electronic ISSN: 1471-2261
DOI: https://doi.org/10.1186/s12872-024-03899-8

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Early changes in cardiac troponin T and NT-proBNP levels in neonates receiving ECMO support: a single-center experience

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