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Open Access 24-03-2024 | Dysphagia | Original Article

Dysphagia Prevalence in Progressive Supranuclear Palsy: A Systematic Review and Meta-Analysis

Authors: Julia Glinzer, Éadaoin Flynn, Eleni Tampoukari, Isolde Harpur, Margaret Walshe

Published in: Dysphagia

Abstract

The objective of this systematic review was to determine the prevalence of dysphagia and aspiration in people with progressive supranuclear palsy (PSP). A search of six electronic databases was performed from inception to April 2022. No context restrictions were set. All primary research comprising figures to derive a prevalence rate were included. Two independent reviewers screened search results. Data were extracted by one reviewer. Conflicts were resolved by discussion with a third reviewer. The quality of included studies was assessed using the JBI Checklist for Prevalence Studies. From 877 studies, 12 were eligible for inclusion. Dysphagia had to be confirmed using instrumental assessments, clinical swallowing evaluation, screening, and patient-reported outcome measures (PROM). A random-effects meta-analysis calculated a pooled dysphagia prevalence in 78–89% (95% CI [60.6, 89.1], [78.9, 95.0]). depending on the chosen assessment method, and a pooled aspiration prevalence of 23.5% (95% CI [14.5, 33.7]). The included studies were of moderate quality, with high risk of selection and coverage bias and low to moderate risk of measurement bias. Dysphagia is highly prevalent in a sample of participants with mostly moderately severe PSP. Aspiration occurs in a quarter of this sample and is likely to increase as the disease progresses. Given the low general prevalence of PSP, studies remain at high risk for selection bias. Prospective research should focus on the development of dysphagia in the course of PSP and its subcategories using instrumental assessment and consider all phases of swallowing.

Registration

The protocol of this systematic review was registered on the International Prospective Register of Systematic Reviews (PROSPERO) in April 2021 (registration number: CRD42021245204).

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Title: Dysphagia Prevalence in Progressive Supranuclear Palsy: A Systematic Review and Meta-Analysis
Authors: Julia Glinzer
Éadaoin Flynn
Eleni Tampoukari
Isolde Harpur
Margaret Walshe
Publication date: 24-03-2024
Publisher: Springer US
Keywords: Dysphagia
Dysphagia
Dysphagia
Progressive Supranuclear Palsy
Aspiration
Published in: Dysphagia
Print ISSN: 0179-051X
Electronic ISSN: 1432-0460
DOI: https://doi.org/10.1007/s00455-024-10681-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Dysphagia Prevalence in Progressive Supranuclear Palsy: A Systematic Review and Meta-Analysis

Abstract

Registration

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Registration

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