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Hepatology International

Do the therapeutic vaccines hold hope for the treatment of hepatitis B?

Published in:
Authors
Qiujing Yan
Xinghuan Fu
Yan Wang
Guiqiang Wang
Published in
Hepatology International | Issue 6/2025

Abstract

Background

Chronic hepatitis B (CHB) is a global disease that can induce severe conditions such as cirrhosis and liver cancer, posing a serious threat to human health. The low functional cure rate of existing antiviral treatment drugs is primarily due to the dysfunctional immune response in CHB patients and the difficulty in clearing intrahepatic cccDNA.

Methods

This article reviews the latest progress in the research on therapeutic vaccines for CHB, to analyze and discuss the potential impact of current achievements and to outline the prospects for future research, exploring therapeutic strategies for the functional cure of CHB.

Results

Therapeutic vaccines are anticipated to activate specific immune responses in CHB patients, break the mechanisms of immune tolerance, and exhibit significant potential in maintaining long-term immune activity. Several therapeutic vaccines have already demonstrated promising therapeutic effects.

Conclusions

Therapeutic vaccines are of great significance in the field of CHB treatment. Current research achievements provide strong support for their application, while combined therapy offers new ideas and hope for future treatment directions.
Title
Do the therapeutic vaccines hold hope for the treatment of hepatitis B?
Authors
Qiujing Yan
Xinghuan Fu
Yan Wang
Guiqiang Wang
Publication date
27-09-2025
Publisher
Springer India
Published in
Hepatology International / Issue 6/2025
Print ISSN: 1936-0533
Electronic ISSN: 1936-0541
DOI
https://doi.org/10.1007/s12072-025-10907-2
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