Top

Published in:

01-10-2018 | Review

Dietary supplements and fatigue in patients with breast cancer: a systematic review

Authors: Paula Tâmara Vieira Teixeira Pereira, Andréa Dias Reis, Renata Rodrigues Diniz, Franciléia Andrade Lima, Richard Diego Leite, Mayara Cristina Pinto da Silva, Rosane Nassar Meireles Guerra, Érica Brandão de Moraes Vieira, João Batista Santos Garcia

Published in: Breast Cancer Research and Treatment | Issue 3/2018

Abstract

Purpose

Cancer-related fatigue (CRF) is defined as a distressing, persistent, and subjective sense of physical or emotional and/or cognitive exhaustion. The treatment of CRF includes pharmacological and non-pharmacological therapies; dietary strategies with promising results have also been used. This study aimed to identify dietary supplements that improve fatigue in patients with breast cancer.

Methods

A systematic review of the literature was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Data were obtained from PubMed, Scopus, MEDLINE, CENTRAL, and CINAHL databases using the following MeSH terms: breast neoplasms, dietary supplements, diet, and fatigue. In addition, the Google and Google Scholar search engines were used to find grey literature. Methodological quality was evaluated using the risk of bias in randomised clinical trials in the systematic Cochrane reviews, and the quality of the evidence was also analysed using the GRADE system.

Results

A total of 893 studies were assessed, of which eight were included in the review, with 932 women diagnosed with breast cancer. The most commonly used supplements that improve fatigue were guarana, acetyl-l-carnitine, and co-enzyme Q10. Two studies had a low risk of bias in all categories and three had high-quality evidence.

Conclusions

Dietary supplements or diet patterns are seldom used to treat fatigue in patients with breast cancer. The results of this review showed that guarana extract and a diet rich in whole foods, omega-3 fatty acids, fruits, and vegetables could be used to treat CRF in patients with breast cancer. The studies had a low risk of bias with high-quality evidence on the efficacy of the interventions in treating fatigue in the study population.

PDQ Adult Treatment Editorial Board (2002) Breast Cancer Treatment (PDQ^®): Health Professional Version (2002) In: PDQ Cancer Information Summaries [Internet]. National Cancer Institute (US), Bethesda. https://www.ncbi.nlm.nih.gov/books/NBK65744/. Accessed 01 Dec 2017

National Comprehensive Cancer Network (2017) Cancer-related fatigue: NCCN Clinical Practice Guidelines in Oncology. https://www.nccn.org/professionals/physician_gls/pdf/fatigue.pdf. Accessed 01 Dec 2017

Ryan JL, Carroll JK, Ryan EP, Mustian KM, Fiscella K, Morrow GR (2007) Mechanisms of cancer-related fatigue. Oncologist 12:22–34. https://doi.org/10.1634/theoncologist.12-S1-22 CrossRefPubMed

Fernández-de-las-Peñasa C, Cantarero-Villanuevac I, Fernández-Laoc C, Ambite-Quesada S, Díaz-Rodríguez L, Rivas-Martínez I, del Moral-Avila R, Arroyo-Morales M (2012) Influence of catechol-o-methyltransferase genotype (Val158Met) on endocrine, sympathetic nervous and mucosal immune systems in breast cancer survivors. Breast 21:199–203. https://doi.org/10.1016/j.breast.2011.09.012 CrossRef

Abrahams HJG, Gielissen MFM, Schmits IC, Verhagen CA, Rovers MM, Knoop H (2016) Risk factors, prevalence, and course of severe fatigue after breast cancer treatment: a meta -analysis involving 12 327 breast cancer survivors Ann Oncol 27: 965–74. https://doi.org/10.1093/annonc/mdw099

Campos MP, Hassan BJ, Riechelmann R, Del Giglio A (2011) Cancer-related fatigue: a review. Rev Assoc Med Bras 57:206–214CrossRef

Barton DL, Liu H, Dakhil SR, Linquist B, Sloan JA, Nichols CR, McGinn TW, Stella PJ, Seeger GR et al (2013) Wisconsin ginseng (Panax quinquefolius) to improve cancer-related fatigue: a randomized, double-blind trial, N07C2. J Natl Cancer Inst 105:1230–1238. https://doi.org/10.1093/jnci/djt181 CrossRefPubMedPubMedCentral

Mitchell AS, Hoffman AJ, Clark JC, DeGennaro RM, Poirier P, Robinson CB, Weisbrod BL (2014) Putting evidence into practice: an update of evidence-based interventions for cancer-related fatigue during and following treatment. Clin J Oncol Nurs 18(l):38–58. https://doi.org/10.1188/14.CJON.S3.38-58 CrossRefPubMed

Samuels N, Schiff E, Ben-Arye E (2014) Non-herbal nutritional supplements for symptom relief in adjuvant breast cancer: creating a doctor-patient dialogue. BMJ Support Palliat Care 4:e1. https://doi.org/10.1136/bmjspcare-2013-000463 CrossRefPubMed

10.

Mustian KM, Alfano CM, Heckler C, Kleckner AS, Kleckner IR, Leach CR, Mohr D, Palesh OG, Peppone LJ et al (2017) Comparison of pharmaceutical, psychological, and exercise treatments for cancer-related fatigue: a meta-analysis. JAMA Oncol 3:961–968. https://doi.org/10.1001/jamaoncol.2016.6914 CrossRefPubMedPubMedCentral

11.

de Oliveira Campos MP, Riechelmann R, Martins LC, Hassan BJ, Casa FB, Del Giglio A (2011) Guarana (Paullinia cupana) improves fatigue in breast cancer patients undergoing systemic chemotherapy. J Altern Complement Med 17:505–512. https://doi.org/10.1089/acm.2010.0571 CrossRefPubMed

12.

Zick SM, Colacino J, Cornellier M, Khabir T, Surnow K, Djuric Z (2017) Fatigue reduction diet in breast cancer survivors: a pilot randomized clinical trial. Breast Cancer Res Treat 161:299–310. https://doi.org/10.1007/s10549-016-4070-y CrossRefPubMed

13.

Moher D, Liberati A, Tetzlaff J, Altman DG (2010) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 8:336–341. https://doi.org/10.1016/j.ijsu.2010.02.007 CrossRefPubMed

14.

Santos CMC, Pimenta CAM, Nobre MRC (2007) A estratégia PICO para a construção da pergunta de pesquisa e busca de evidências. Rev Lat Am Enferm 15:508–511CrossRef

15.

Carvalho APV, Silva V, Grande AJ (2013) Avaliação do risco de viés de ensaios clínicos randomizados pela Ferramenta da Colaboração Cochrane. Diagn Trat 18:38–44

16.

Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Schünemann HJ (2008) GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 336:924–926. https://doi.org/10.1136/bmj.39489.470347 CrossRefPubMedPubMedCentral

17.

Albarnaz MD (2017) Efetividade do guaraná (Paullinia cupana) para manejo da fadiga em mulheres com câncer de mama em quimioterapia: um ensaio clínico, duplo cego, randomizado. Dissertation, Federal University of Goiás

18.

Hershman DL, Unger JM, Crew KD et al (2013) Randomized double-blind placebo-controlled trial of acetyl-l-carnitine for the prevention of taxane-induced neuropathy in women undergoing adjuvant breast cancer therapy. J Clin Oncol 31:2627–2633. https://doi.org/10.1200/JCO.2012.44.8738 CrossRefPubMedPubMedCentral

19.

Lesser GJ, Case D, Stark N, Minasian LM, Awad D, Moinpour CM, Hansen L, Lew DL, Greenlee H, Fehrenbacher L et al (2013) A randomized, double-blind, placebo-controlled study of oral coenzyme Q10 to relieve self-reported treatment-related fatigue in newly diagnosed patients with breast cancer. J Support Oncol 11:31–42. https://doi.org/10.1016/j.suponc.2012.03.003 PubMedPubMedCentralCrossRef

20.

Iwase S, Kawaguchi T, Yotsumoto D, Doi T, Miyara K, Odagiri H, Kitamura K, Ariyoshi K, Miyaji T et al (2016) Efficacy and safety of an amino acid jelly containing coenzyme Q10 and L-carnitine in controlling fatigue in breast cancer patients receiving chemotherapy: a multi-institutional, randomized, exploratory trial (JORTC-CAM01). Support Care Cancer 24:637–646. https://doi.org/10.1007/s00520-015-2824-4 CrossRef

21.

Noguchi N, Maruyama I, Yamada A (2014) The influence of chlorella and its hot water extract supplementation on quality of life in patients with breast cancer. Evidence-based complementary and alternative medicine. Evid Based Complement Alternat Med 2014:704619. https://doi.org/10.1155/2014/704619

22.

Law KS, Azman N, Omar EA, Musa MY, Yusoff NM, Sulaiman SA, Hussain NH (2014) The effects of virgin coconut oil (VCO) as supplementation on quality of life (QOL) among breast cancer patients. Lipids Health Dis 13:139–146. https://doi.org/10.1186/1476-511X-13-139 CrossRefPubMedPubMedCentral

23.

Ebede CC, Jang Y, Escalante CP (2017) Cancer-related fatigue in cancer survivorship. Med Clin North Am 101:1085–1097. https://doi.org/10.1016/j.mcna.2017.06.007 CrossRefPubMed

24.

Goedendorp MM, Jacobsen PB, Andrykowski MA (2016) Fatigue screening in breast cancer patients: identifying likely cases of cancer-related fatigue. Psychooncology 25:275–281. https://doi.org/10.1002/pon.3907 CrossRefPubMed

25.

Greenlee H, DuPont-Reyes MJ, Balneaves LG, Carlson LE, Cohen MR, Deng G, Johnson JA, Mumber M, Seely D et al (2017) Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment. CA Cancer J Clin 67:194–232. https://doi.org/10.3322/caac.21397 CrossRefPubMedPubMedCentral

26.

Limon-Miro AT, Lopez-Teros V, Astiazaran-Garcia H (2017) Dietary guidelines for breast cancer patients: a critical review. Adv Nutr 8:613–623. https://doi.org/10.3945/an.116.014423 PubMedPubMedCentralCrossRef

27.

Guest DD, Evans EM, Rogers LQ (2013) Diet components associated with perceived fatigue in breast cancer survivors. Eur J Cancer Care 22:51–59. https://doi.org/10.1111/j.1365-2354.2012.01368 CrossRef

28.

Lopes CM, Dourado A, Oliveira R (2017) Phytotherapy and nutritional supplements on breast cancer. BioMed Res Int 2017:1–43. https://doi.org/10.1155/2017/7207983 CrossRef

Title: Dietary supplements and fatigue in patients with breast cancer: a systematic review
Authors: Paula Tâmara Vieira Teixeira Pereira
Andréa Dias Reis
Renata Rodrigues Diniz
Franciléia Andrade Lima
Richard Diego Leite
Mayara Cristina Pinto da Silva
Rosane Nassar Meireles Guerra
Érica Brandão de Moraes Vieira
João Batista Santos Garcia
Publication date: 01-10-2018
Publisher: Springer US
Published in: Breast Cancer Research and Treatment / Issue 3/2018
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-018-4857-0

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras

Prof. Fabrice Barlesi

Developed by: Springer Medicine

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 3/2018

Optimal vascular access strategies for patients receiving chemotherapy for early-stage breast cancer: a systematic review

The effect of participation in neoadjuvant clinical trials on outcomes in patients with early breast cancer

Correction to: Persistent major alopecia following adjuvant docetaxel for breast cancer: incidence, characteristics, and prevention with scalp cooling

Breast cancer and its impact in male transsexuals

Protein N-glycosylation alteration and glycolysis inhibition both contribute to the antiproliferative action of 2-deoxyglucose in breast cancer cells

Thyroid hormone receptor beta-1 expression in early breast cancer: a validation study

Keynote webinar | Spotlight on antibody–drug conjugates in cancer