Diabetologia

Up Front

The changing landscape of scientific communication at EASD

Chantal Mathieu, Eleanor Kennedy, Patrick Schrauwen, Hindrik Mulder

Consortium-based approach to receiving an EMA qualification opinion on the use of islet autoantibodies as enrichment biomarkers in type 1 diabetes clinical studies

Stephen R. Karpen, Jessica L. Dunne, Brigitte I. Frohnert, Marjana Marinac, Claudia Richard, Sarah E. David, Inish M. O’Doherty

Cardiovascular outcomes in type 1 and type 2 diabetes

Annika Rosengren, Pigi Dikaiou

Identification of monogenic variants in more than ten per cent of children without type 1 diabetes-related autoantibodies at diagnosis in the Finnish Pediatric Diabetes Register

Minna Harsunen, Jarno L. T. Kettunen, Taina Härkönen, Om Dwivedi, Mikko Lehtovirta, Paula Vähäsalo, Riitta Veijola, Jorma Ilonen, Päivi J. Miettinen, Mikael Knip, Tiinamaija Tuomi

Exercise as a non-pharmacological intervention to protect pancreatic beta cells in individuals with type 1 and type 2 diabetes

Alexandra Coomans de Brachène, Corentin Scoubeau, Anyïshai E. Musuaya, Jose Maria Costa-Junior, Angela Castela, Julie Carpentier, Vitalie Faoro, Malgorzata Klass, Miriam Cnop, Decio L. Eizirik

Timing of physical activity in relation to liver fat content and insulin resistance

Jeroen H. P. M. van der Velde, Sebastiaan C. Boone, Esther Winters-van Eekelen, Matthijs K. C. Hesselink, Vera B. Schrauwen-Hinderling, Patrick Schrauwen, Hildo J. Lamb, Frits R. Rosendaal, Renée de Mutsert

Advanced glycation end-products, cardiac function and heart failure in the general population: The Rotterdam Study

Banafsheh Arshi, Jinluan Chen, M. Arfan Ikram, M. Carola Zillikens, Maryam Kavousi

Kidney function measures and cardiovascular outcomes in people with diabetes: the Hoorn Diabetes Care System cohort

Elisa Dal Canto, Petra J. M. Elders, Amber A. van der Heijden, Adriana J. van Ballegooijen, Birgit I. Lissenberg-Witte, Femke Rutters, Joline W. J. Beulens

High-throughput genetic clustering of type 2 diabetes loci reveals heterogeneous mechanistic pathways of metabolic disease

Hyunkyung Kim, Kenneth E. Westerman, Kirk Smith, Joshua Chiou, Joanne B. Cole, Timothy Majarian, Marcin von Grotthuss, Soo Heon Kwak, Jaegil Kim, Josep M. Mercader, Jose C. Florez, Kyle Gaulton, Alisa K. Manning, Miriam S. Udler

The effect of age on longitudinal measures of beta cell function and insulin sensitivity during the progression of early stage type 1 diabetes

Ele Ferrannini, Andrea Mari, Gabriela S. F. Monaco, Jay S. Skyler, Carmella Evans-Molina

Stratifying risk for onset of type 1 diabetes using islet autoantibody trajectory clustering

Sejal Mistry, Ramkiran Gouripeddi, Vandana Raman, Julio C. Facelli

Pancreatic alpha cell glucagon–liver FGF21 axis regulates beta cell regeneration in a mouse model of type 2 diabetes

Xiaona Cui, Jin Feng, Tianjiao Wei, Linxi Zhang, Shan Lang, Kun Yang, Jin Yang, Junling Liu, Michael Sterr, Heiko Lickert, Rui Wei, Tianpei Hong

Gene expression profiling in NOD mice reveals that B cells are highly educated by the pancreatic environment during autoimmune diabetes

Joanne Boldison, Jessica R. Hopkinson, Joanne Davies, James A. Pearson, Pia Leete, Sarah Richardson, Noel G. Morgan, F. Susan Wong

Distinct subcellular localisation of intramyocellular lipids and reduced PKCε/PKCθ activity preserve muscle insulin sensitivity in exercise-trained mice

Rafael C. Gaspar, Kun Lyu, Brandon T. Hubbard, Brooks P. Leitner, Panu K. Luukkonen, Sandro M. Hirabara, Ikki Sakuma, Ali Nasiri, Dongyan Zhang, Mario Kahn, Gary W. Cline, José Rodrigo Pauli, Rachel J. Perry, Kitt F. Petersen, Gerald I. Shulman

Serum neurofilament light chain: a novel biomarker for early diabetic sensorimotor polyneuropathy

Haifa Maalmi, Alexander Strom, Agnese Petrera, Stefanie M. Hauck, Klaus Strassburger, Oliver Kuss, Oana-Patricia Zaharia, Gidon J. Bönhof, Wolfgang Rathmann, Sandra Trenkamp, Volker Burkart, Julia Szendroedi, Dan Ziegler, Michael Roden, Christian Herder

CCR2-positive monocytes contribute to the pathogenesis of early diabetic retinopathy in mice

Aicha Saadane, Alexander A. Veenstra, Martin S. Minns, Jie Tang, Yunpeng Du, Fatima Abubakr Elghazali, Emma M. Lessieur, Eric Pearlman, Timothy S. Kern

Utility of islet autoantibodies as enrichment biomarkers in type 1 diabetes clinical studies: a viewpoint from the FDA

Justin Penzenstadler, Justin C. Earp, Lauren K. Wood Heickman, Kristen Pluchino

GLP1RAs vs SGLT2is were associated with lower risk of major adverse limb events and similar risks of heart failure hospitalisation and stroke?

Lixin Du, Pan Wang, Hongwei Chen, Yu Zhang, Jianlan Ma