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Cardiovascular Diabetology
Published in: Cardiovascular Diabetology 1/2008

Open Access 01-12-2008 | Original investigation

Diabetic retinopathy is associated with pulse wave velocity, not with the augmentation index of pulse waveform

Authors: Osamu Ogawa, Kiyoko Hiraoka, Takahiro Watanabe, Junichiro Kinoshita, Masahiko Kawasumi, Hidenori Yoshii, Ryuzo Kawamori

Published in: Cardiovascular Diabetology | Issue 1/2008

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Abstract

Background

To investigate the clinical differences between pulse wave velocity and augmentation index in diabetic retinopathy.

Methods

The subjects were 201 patients with type 2 diabetes. These subjects were measured for both augmentation index (AI) and brachial-ankle pulse wave velocity (baPWV) by a pulse wave analyzer. The relationships between AI, baPWV, and diabetic retinopathy were examined.

Results

BaPWV was significantly higher in patients with diabetic retinopathy than in individuals without the disease. (20.13 ± 3.66 vs.17.14 ± 3.60 m/s p < 0.001) AI was higher in patients with diabetic retinopathy, but not significantly. (19.5 ± 15.2 vs. 14.8 ± 20.5% p = 0.14) The association between baPWV and diabetic retinopathy remained statistically significant after adjustment. (Odds ratio: 1.21 Per m/s, 95% confidence interval: 1.07–1.37) On the other hand, the association between AI and diabetic retinopathy was not statistically significant. (Odds ratio: 1.01 Per %, 95% confidence interval: 0.98–1.03)

Conclusion

BaPWV is associated with diabetic retinopathy, but AI is not. The clinical significance appears to be different between PWV and AI in patients with diabetes.
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Metadata
Title
Diabetic retinopathy is associated with pulse wave velocity, not with the augmentation index of pulse waveform
Authors
Osamu Ogawa
Kiyoko Hiraoka
Takahiro Watanabe
Junichiro Kinoshita
Masahiko Kawasumi
Hidenori Yoshii
Ryuzo Kawamori
Publication date
01-12-2008
Publisher
BioMed Central
Published in
Cardiovascular Diabetology / Issue 1/2008
Electronic ISSN: 1475-2840
DOI
https://doi.org/10.1186/1475-2840-7-11

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