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Cardiovascular Diabetology
Published in: Cardiovascular Diabetology 1/2008

Open Access 01-12-2008 | Review

The clinical relevance of assessing advanced glycation endproducts accumulation in diabetes

Authors: Robbert Meerwaldt, Thera Links, Clark Zeebregts, Rene Tio, Jan-Luuk Hillebrands, Andries Smit

Published in: Cardiovascular Diabetology | Issue 1/2008

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Abstract

Cardiovascular disease is the major cause of morbidity and mortality associated with diabetes. There is increasing evidence that advanced glycation endproducts (AGEs) play a pivotal role in atherosclerosis, in particular in diabetes. AGE accumulation is a measure of cumulative metabolic and oxidative stress, and may so represent the "metabolic memory". Furthermore, increased AGE accumulation is closely related to the development of cardiovascular complications in diabetes. This review article will focus on the clinical relevance of measuring AGE accumulation in diabetic patients by focusing on AGE formation, AGEs as predictors of long-term complications, and interventions against AGEs.
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Metadata
Title
The clinical relevance of assessing advanced glycation endproducts accumulation in diabetes
Authors
Robbert Meerwaldt
Thera Links
Clark Zeebregts
Rene Tio
Jan-Luuk Hillebrands
Andries Smit
Publication date
01-12-2008
Publisher
BioMed Central
Published in
Cardiovascular Diabetology / Issue 1/2008
Electronic ISSN: 1475-2840
DOI
https://doi.org/10.1186/1475-2840-7-29

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