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BMC Cardiovascular Disorders

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Open Access 01-12-2021 | Diabetes | Research article

Association of monocyte-to-high density lipoprotein ratio with arterial stiffness in patients with diabetes

Authors: Dyah Samti Mayasari, Nahar Taufiq, Hariadi Hariawan

Published in: BMC Cardiovascular Disorders | Issue 1/2021

Abstract

Background

Previous studies proposed that chronic inflammation in diabetes has a role in abnormal collagen production and elastin degradation, which promotes arterial stiffness. Monocyte-to-High Density Lipoprotein cholesterol ratio (MHR) is a simple measurement associated with inflammation and oxidative stress. However, little is known about the relationship of MHR with arterial stiffness. This study aimed to determine the association of MHR with arterial stiffness in patients with diabetes.

Methods

A total of 81 patients with type 2 diabetes mellitus were enrolled in a cross-sectional study. Arterial stiffness factor in this study was Cardio Ankle Vascular Index (CAVI). We analyzed complete blood count and lipid profile in all participants, then performed statistical analysis to determine the relationship between MHR and CAVI. Receiver operating characteristic (ROC) analysis was used to estimate the cut-off values of MHR to predict CAVI ≥ 9.

Results

Median of MHR in this study was 11.91 with the mean of CAVI was 8.13 ± 0.93. Spearman correlation analysis revealed a significant positive correlation between MHR and CAVI (ρ = 0.239, p = 0.031). Multivariate analysis showed the independent association of MHR to arterial stiffness (β = 0.361, 95% CI 0.023–0.093) and to CAVI ≥ 9 (OR 1.181, 95% CI 1.047–1.332). The cut-off values of MHR for predicting CAVI ≥ 9 were identified as ≥ 13 (OR 3.289, 95% CI 1.036–10.441).

Conclusion

MHR is associated with CAVI in patients with diabetes, irrespective of various potential confounders.

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Title: Association of monocyte-to-high density lipoprotein ratio with arterial stiffness in patients with diabetes
Authors: Dyah Samti Mayasari
Nahar Taufiq
Hariadi Hariawan
Publication date: 01-12-2021
Publisher: BioMed Central
Keyword: Diabetes
Published in: BMC Cardiovascular Disorders / Issue 1/2021
Electronic ISSN: 1471-2261
DOI: https://doi.org/10.1186/s12872-021-02180-6

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Association of monocyte-to-high density lipoprotein ratio with arterial stiffness in patients with diabetes

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Results

Conclusion

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