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BMC Infectious Diseases
Published in: BMC Infectious Diseases 1/2009

Open Access 01-12-2009 | Case report

Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies

Authors: Denis Malvy, Khaled Ezzedine, Maria Mamani-Matsuda, Brigitte Autran, Hugues Tolou, Marie-Catherine Receveur, Thierry Pistone, Jérome Rambert, Daniel Moynet, Djavad Mossalayi

Published in: BMC Infectious Diseases | Issue 1/2009

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Abstract

Background

Chikungunya fever is an emerging arboviral disease characterized by an algo-eruptive syndrome, inflammatory polyarthralgias, or tenosynovitis that can last for months to years. Up to now, the pathophysiology of the chronic stage is poorly understood.

Case presentation

We report the first case of CHIKV infection with chronic associated rheumatism in a patient who developed progressive erosive arthritis with expression of inflammatory mediators and persistence of specific IgM antibodies over 24 months following infection.

Conclusions

Understanding the specific features of chikungunya virus as well as how the virus interacts with its host are essential for the prevention, treatment or cure of chikungunya disease.
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Metadata
Title
Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies
Authors
Denis Malvy
Khaled Ezzedine
Maria Mamani-Matsuda
Brigitte Autran
Hugues Tolou
Marie-Catherine Receveur
Thierry Pistone
Jérome Rambert
Daniel Moynet
Djavad Mossalayi
Publication date
01-12-2009
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2009
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/1471-2334-9-200

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