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Seminars in Immunopathology
Published in: Seminars in Immunopathology 2/2017

01-02-2017 | Review

Dendritic cells as gatekeepers of tolerance

Authors: Ari Waisman, Dominika Lukas, Björn E. Clausen, Nir Yogev

Published in: Seminars in Immunopathology | Issue 2/2017

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Abstract

Dendritic cells (DC) are unique hematopoietic cells, linking innate and adaptive immune responses. In particular, they are considered as the most potent antigen presenting cells, governing both T cell immunity and tolerance. In view of their exceptional ability to present antigen and to interact with T cells, DC play distinct roles in shaping T cell development, differentiation and function. The outcome of the DC-T cell interaction is determined by the state of DC maturation, the type of DC subset, the cytokine microenvironment and the tissue location. Both regulatory T cells (Tregs) and DC are indispensable for maintaining central and peripheral tolerance. Over the past decade, accumulating data indicate that DC critically contribute to Treg differentiation and homeostasis.
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Metadata
Title
Dendritic cells as gatekeepers of tolerance
Authors
Ari Waisman
Dominika Lukas
Björn E. Clausen
Nir Yogev
Publication date
01-02-2017
Publisher
Springer Berlin Heidelberg
Published in
Seminars in Immunopathology / Issue 2/2017
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-016-0583-z

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