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01-02-2017 | Review

Dendritic cells and parasites: from recognition and activation to immune response instruction

Authors: Claudia Cristina Motran, Laura Fernanda Ambrosio, Ximena Volpini, Daiana Pamela Celias, Laura Cervi

Published in: Seminars in Immunopathology | Issue 2/2017

Abstract

The effective defense against parasite infections requires the ability to mount an appropriate and controlled specific immune response able to eradicate the invading pathogen while limiting the collateral damage to self-tissues. Dendritic cells are key elements for the development of immunity against parasites; they control the responses required to eliminate these pathogens while maintaining host homeostasis. Ligation of dendritic cell pattern recognition receptors by pathogen-associated molecular pattern present in the parasites initiates signaling pathways that lead to the production of surface and secreted proteins that are required, together with the antigen, to induce an appropriate and timely regulated immune response. There is evidence showing that parasites can influence and regulate dendritic cell functions in order to promote a more permissive environment for their survival. In this review, we will focus on new insights about the ability of protozoan and helminth parasites or their products to modify dendritic cell function and discuss how this interaction is crucial in shaping the host response.

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Title: Dendritic cells and parasites: from recognition and activation to immune response instruction
Authors: Claudia Cristina Motran
Laura Fernanda Ambrosio
Ximena Volpini
Daiana Pamela Celias
Laura Cervi
Publication date: 01-02-2017
Publisher: Springer Berlin Heidelberg
Published in: Seminars in Immunopathology / Issue 2/2017
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-016-0588-7

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