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Current Nutrition Reports
Published in: Current Nutrition Reports 4/2018

Open Access 01-12-2018 | Cardiovascular Disease (JHY Wu, Section Editor)

Dairy Consumption and Cardiometabolic Diseases: Systematic Review and Updated Meta-Analyses of Prospective Cohort Studies

Authors: Sabita S. Soedamah-Muthu, Janette de Goede

Published in: Current Nutrition Reports | Issue 4/2018

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Abstract

Purpose of Review

Dairy products contain both beneficial and harmful nutrients in relation to cardiometabolic diseases. Here, we provide the latest scientific evidence regarding the relationship between dairy products and cardiometabolic diseases by reviewing the literature and updating meta-analyses of observational studies.

Recent Findings

We updated our previous meta-analyses of cohort studies on type 2 diabetes, coronary heart disease (CHD), and stroke with nine studies and confirmed previous results. Total dairy and low-fat dairy (per 200 g/d) were inversely associated with a 3–4% lower risk of diabetes. Yogurt was non-linearly inversely associated with diabetes (RR = 0.86, 95% CI: 0.83–0.90 at 80 g/d). Total dairy and milk were not associated with CHD (RR~1.0). An increment of 200 g of daily milk intake was associated with an 8% lower risk of stroke.

Summary

The latest scientific evidence confirmed neutral or beneficial associations between dairy products and risk of cardiometabolic diseases.
Appendix
Available only for authorised users
Literature
1.
• Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration. Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment. Lancet Diabetes Endocrinol. 2014;2(8):634–47. This study highlights the importance of lowering cardiometabolic risks through dietary, behavioural, and pharmacological interventions as part of the global public health policies. CrossRef
2.
• Global Burden of Disease Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1345–422. The Global Burden of Diseases Collaboration estimated in 2016 that the leading risk factors in terms of attributable disability adjusted life-years (DALYs) worldwide were malnutrition, diet, high blood pressure, smoking, and air pollution. This highlights the importance of diet as contributing factor to health loss. CrossRef
3.
Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the global burden of disease study 2010. Lancet. 2012;380(9859):2224–60.PubMedPubMedCentralCrossRef
4.
Mozaffarian D, Ludwig DS. Dietary guidelines in the 21st century--a time for food. JAMA. 2010;304(6):681–2.PubMedCrossRef
5.
Centre National Interprofessionnel de l'Economie Laitière (CNIEL)/ International Dairy Federation (IDF), Food and Agriculture Organization (FAO) Food Outlook, PRB. Per capita milk consumption from 2006 to 2012. Annual National Workshop for Dairy Economists and Policy Analysts presented in Boston in May 2013.
6.
U.S. Department of Agriculture and U.S. Department of Health and Human Services. Dietary Guidelines for Americans. 7th Edition, Washington, DC: U.S. Government Printing Office; December 2010.
7.
8.
Ge K. The transition of Chinese dietary guidelines and food guide pagoda. Asia Pac J Clin Nutr. 2011;20(3):439–46.PubMed
9.
10.
11.
Brink L, Postma-Smeets A, Stafleu A, Wolvers D. Richtlijnen Schijf van Vijf, Voedingscentrum. Voedingscentrum: Den Haag; 2016.
12.
Mozaffarian D, Wu JHY. Flavonoids, dairy foods, and cardiovascular and metabolic health: a review of emerging biologic pathways. Circ Res. 2018;122(2):369–84.PubMedCrossRefPubMedCentral
13.
van Aerde MA, Soedamah-Muthu SS, Geleijnse JM, Snijder MB, Nijpels G, Stehouwer CD, et al. Dairy intake in relation to cardiovascular disease mortality and all-cause mortality: the Hoorn study. Eur J Nutr. 2013;52(2):609–16.PubMedCrossRef
14.
15.
16.
Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab. 2007;92(6):2017–29.PubMedCrossRef
17.
Elwood PC, Givens DI, Beswick AD, Fehily AM, Pickering JE, Gallacher J. The survival advantage of milk and dairy consumption: an overview of evidence from cohort studies of vascular diseases, diabetes and cancer. J Am Coll Nutr. 2008;27(6):723s–34s.PubMedCrossRef
18.
Tong X, Dong JY, Wu ZW, Li W, Qin LQ. Dairy consumption and risk of type 2 diabetes mellitus: a meta-analysis of cohort studies. Eur J Clin Nutr. 2011;65(9):1027–31.PubMedCrossRef
19.
20.
Tremblay A, Gilbert JA. Milk products, insulin resistance syndrome and type 2 diabetes. J Am Coll Nutr. 2009;28(Suppl 1):91S–102S.PubMedCrossRef
21.
• Soedamah-Muthu SS, Ding EL, Al-Delaimy WK, Hu FB, Engberink MF, Willett WC, et al. Milk and dairy consumption and incidence of cardiovascular diseases and all-cause mortality: dose-response meta-analysis of prospective cohort studies. Am J Clin Nutr. 2011;93(1):158–71. This dose-response meta-analysis of prospective studies in 2011 on dairy products in relation to CVD and all-cause mortality risk, was the first dose-reponse meta-analysis to indicate that milk intake was not associated with all-cause mortality but possibly inversely associated with overall CVD or stroke risk; however, these findings were based on limited numbers and limited dairy products (focus on milk). PubMedCrossRef
22.
Kratz M, Baars T, Guyenet S. The relationship between high-fat dairy consumption and obesity, cardiovascular, and metabolic disease. Eur J Nutr. 2013;52(1):1–24.PubMedCrossRef
23.
•• Gijsbers L, Ding EL, Malik VS, de Goede J, Geleijnse JM, Soedamah-Muthu SS. Consumption of dairy foods and diabetes incidence: a dose-response meta-analysis of observational studies. Am J Clin Nutr. 2016;103(4):1111–24. This dose-response systematic review and meta-analysis indicated a possible role for dairy foods, particularly yogurt, in the prevention of type 2 diabetes. PubMedCrossRef
24.
•• de Goede J, Soedamah-Muthu SS, Pan A, Gijsbers L, Geleijnse JM. Dairy consumption and risk of stroke: a systematic review and updated dose-response meta-analysis of prospective cohort studies. J Am Heart Assoc. 2016;5(5). https://​doi.​org/​10.​1161/​JAHA.​115.​002787. This systematic review and dose-response meta-analysis of milk and other dairy products in relation to stroke risk showed that milk consumption was inversely associated with stroke risk, especially in Asian countries. Cheese intake was marginally inversely associated with stroke risk.
25.
•• Guo J, Astrup A, Lovegrove JA, Gijsbers L, Givens DI, Soedamah-Muthu SS. Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality: dose-response meta-analysis of prospective cohort studies. Eur J Epidemiol. 2017;32(4):269–87. This is a systematic review and dose-response meta-analysis of milk and other dairy products in relation to CVD, CHD and all-cause mortality. In general neutral or inverse associations were found for dairy products and these outcomes. PubMedPubMedCentralCrossRef
26.
Chen GC, Wang Y, Tong X, Szeto IMY, Smit G, Li ZN, et al. Cheese consumption and risk of cardiovascular disease: a meta-analysis of prospective studies. Eur J Nutr. 2017;56(8):2565–75.PubMedCrossRef
27.
Dinicolantonio JJ, Harcombe Z, O'Keefe JH. Problems with the 2015 dietary guidelines for Americans. An Alternative. Minn Med. 2016;99(6):40–3.PubMed
28.
Brouwer-Brolsma EM, van Woudenbergh GJ, Oude Elferink SJ, Singh-Povel CM, Hofman A, Dehghan A, et al. Intake of different types of dairy and its prospective association with risk of type 2 diabetes: the Rotterdam study. Nutr Metab Cardiovasc Dis. 2016;26(11):987–95.PubMedCrossRef
29.
Hruby A, Ma J, Rogers G, Meigs JB, Jacques PF. Associations of dairy intake with incident prediabetes or diabetes in middle-aged adults vary by both dairy type and glycemic status. J Nutr. 2017;147(9):1764–75.PubMedPubMedCentral
30.
Virtanen HEK, Koskinen TT, Voutilainen S, Mursu J, Tuomainen TP, Kokko P, et al. Intake of different dietary proteins and risk of type 2 diabetes in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. Br J Nutr. 2017;117(6):882–93.PubMedCrossRef
31.
Talaei M, Pan A, Yuan JM, Koh WP. Dairy intake and risk of type 2 diabetes. Clin Nutr. 2018;37(2):712–8.PubMedCrossRef
32.
Haring B, Misialek JR, Rebholz CM, Petruski-Ivleva N, Gottesman RF, Mosley TH, et al. Association of dietary protein consumption with incident silent cerebral infarcts and stroke: the Atherosclerosis Risk in Communities (ARIC) study. Stroke. 2015;46(12):3443–50.PubMedPubMedCentralCrossRef
33.
Talaei M, Hosseini N, van Dam RM, Sadeghi M, Oveisgharan S, Dianatkhah M, et al. Whole milk consumption and risk of cardiovascular disease and mortality: Isfahan cohort study. Eur J Nutr. 2017;56(7):2343–52.PubMedCrossRef
34.
Buckland G, Gonzalez CA, Agudo A, Vilardell M, Berenguer A, Amiano P, et al. Adherence to the Mediterranean diet and risk of coronary heart disease in the Spanish EPIC cohort study. Am J Epidemiol. 2009;170(12):1518–29.PubMedCrossRef
35.
Dilis V, Katsoulis M, Lagiou P, Trichopoulos D, Naska A, Trichopoulou A. Mediterranean diet and CHD: the Greek European prospective investigation into cancer and nutrition cohort. Br J Nutr. 2012;108(4):699–709.PubMedCrossRef
36.
Talaei M, Koh WP, Yuan JM, Pan A. The association between dairy product intake and cardiovascular disease mortality in Chinese adults. Eur J Nutr. 2017;56(7):2343–52.PubMedCrossRef
37.
Food Standards Agency. Food portion sizes. 3rd ed. Norwich, London: TSO; 2005.
38.
Bodner-Montville J, Ahuja JKC, Ingwersen LA, Haggerty ES, Enns CW, Perloff BP. USDA Food and Nutrient Database for dietary studies: released on the web. J Food Compos Anal. 2006;19(SUPPL):S100–S7.CrossRef
39.
Greenland S, Longnecker MP. Methods for trend estimation from summarized dose-response data, with applications to meta-analysis. Am J Epidemiol. 1992;135(11):1301–9.PubMedCrossRef
40.
Bauer SR, Hankinson SE, Bertone-Johnson ER, Ding EL. Plasma vitamin D levels, menopause, and risk of breast cancer: dose-response meta-analysis of prospective studies. Medicine (Baltimore). 2013;92(3):123–31.CrossRef
41.
Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539–58.PubMedCrossRef
42.
•• Drouin-Chartier JP, Brassard D, Tessier-Grenier M, Cote JA, Labonte ME, Desroches S, et al. Systematic review of the association between dairy product consumption and risk of cardiovascular-related clinical outcomes. Adv Nutr. 2016;7(6):1026–40. This is a systematic review including summaries of earlier published meta-analyses on prospective cohort studies associating dairy consumption with cardiometabolic diseases. The main conclusion was that the consumption of various forms of dairy products showed either favorable or neutral associations with cardiometabolic diseases. Further research was recommended to study effects of full and low-fat dairy on cardiometabolic diseases. PubMedPubMedCentralCrossRef
43.
•• Yu E, Hu FB. Dairy products, dairy fatty acids, and the prevention of cardiometabolic disease: a review of recent evidence. Curr Atheroscler Rep. 2018;20(5):24. This recent review contains summaries of meta-analyses and showed that null or weak inverse associations were shown between consumption of dairy products and risk of cardiovascular disease. Replacing dairy fat with polyunsaturated fatty acids, especially from plant-based foods, may confer further health benefits. PubMedCrossRefPubMedCentral
44.
Aune D, Norat T, Romundstad P, Vatten LJ. Dairy products and the risk of type 2 diabetes: a systematic review and dose-response meta-analysis of cohort studies. Am J Clin Nutr. 2013;98(4):1066–83.PubMedCrossRef
45.
Gao D, Ning N, Wang C, Wang Y, Li Q, Meng Z, et al. Dairy products consumption and risk of type 2 diabetes: systematic review and dose-response meta-analysis. PLoS One. 2013;8(9):e73965.PubMedPubMedCentralCrossRef
46.
Chen M, Sun Q, Giovannucci E, Mozaffarian D, Manson JE, Willett WC, et al. Dairy consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis. BMC Med. 2014;12:215.PubMedPubMedCentralCrossRef
47.
Sluijs I, Forouhi NG, Beulens JW, van der Schouw YT, Agnoli C, Arriola L, et al. The amount and type of dairy product intake and incident type 2 diabetes: results from the EPIC-InterAct study. Am J Clin Nutr. 2012;96(2):382–90.PubMedCrossRef
48.
Schwingshackl L, Hoffmann G, Lampousi AM, Knuppel S, Iqbal K, Schwedhelm C, et al. Food groups and risk of type 2 diabetes mellitus: a systematic review and meta-analysis of prospective studies. Eur J Epidemiol. 2017;32(5):363–75.PubMedPubMedCentralCrossRef
49.
Moslehi N, Shab-Bidar S, Mirmiran P, Sadeghi M, Azizi F. Associations between dairy products consumption and risk of type 2 diabetes: Tehran lipid and glucose study. Int J Food Sci Nutr. 2015;66(6):692–9.PubMedCrossRef
50.
Fuhrman BJ, Smit E, Crespo CJ, Garcia-Palmieri MR. Coffee intake and risk of incident diabetes in Puerto Rican men: results from the Puerto Rico Heart Health Program. Public Health Nutr. 2009;12(6):842–8.PubMedCrossRef
51.
Nettleton JA, Steffen LM, Ni H, Liu K, Jacobs DR Jr. Dietary patterns and risk of incident type 2 diabetes in the multi-ethnic study of atherosclerosis (MESA). Diabetes Care. 2008;31(9):1777–82.PubMedPubMedCentralCrossRef
52.
O'Connor LM, Lentjes MA, Luben RN, Khaw KT, Wareham NJ, Forouhi NG. Dietary dairy product intake and incident type 2 diabetes: a prospective study using dietary data from a 7-day food diary. Diabetologia. 2014;57(5):909–17.PubMedPubMedCentralCrossRef
53.
54.
Villegas R, Gao YT, Dai Q, Yang G, Cai H, Li H, et al. Dietary calcium and magnesium intakes and the risk of type 2 diabetes: the Shanghai Women's Health Study. Am J Clin Nutr. 2009;89(4):1059–67.PubMedPubMedCentralCrossRef
55.
Ericson U, Hellstrand S, Brunkwall L, Schulz CA, Sonestedt E, Wallstrom P, et al. Food sources of fat may clarify the inconsistent role of dietary fat intake for incidence of type 2 diabetes. Am J Clin Nutr. 2015;101(5):1065–80.PubMedCrossRef
56.
Grantham NM, Magliano DJ, Hodge A, Jowett J, Meikle P, Shaw JE. The association between dairy food intake and the incidence of diabetes in Australia: the Australian Diabetes Obesity and Lifestyle Study (AusDiab). Public Health Nutr. 2013;16(2):339–45.PubMedCrossRef
57.
Choi HK, Willett WC, Stampfer MJ, Rimm E, Hu FB. Dairy consumption and risk of type 2 diabetes mellitus in men: a prospective study. Arch Intern Med. 2005;165(9):997–1003.PubMedCrossRef
58.
Talaei M, Pan A, Yuan JM, Koh WP. Reply to Kawada letter to editor about “dairy intake and risk of type 2 diabetes”. Clin Nutr. 2017;36(6):1738.PubMedCrossRef
59.
• Bechthold A, Boeing H, Schwedhelm C, Hoffmann G, Knuppel S, Iqbal K, et al. Food groups and risk of coronary heart disease, stroke and heart failure: a systematic review and dose-response meta-analysis of prospective studies. Crit Rev Food Sci Nutr. 2017 Oct 17:1-20. https://​doi.​org/​10.​1080/​10408398.​2017.​1392288. This review of prospective cohort studies comprised 12 main food groups, including dairy foods, in relation to stroke, coronary heart disease and heart failure. Similar null associations for total dairy, full and low-fat dairy were reported as in other reviews and meta-analyses, although specific dairy foods were not analysed.
60.
• Gille D, Schmid A, Walther B, Vergeres G. Fermented food and non-communicable chronic diseases: a review. Nutrients. 2018 Apr 4;10(4). https://​doi.​org/​10.​3390/​nu10040448. This review summarised meta-analyses of prospective cohort studies and randomized controlled trials on fermented foods, including fermented dairy, and chronic diseases. PubMedCentralCrossRef
61.
Alexander DD, Bylsma LC, Vargas AJ, Cohen SS, Doucette A, Mohamed M, et al. Dairy consumption and CVD: a systematic review and meta-analysis. Br J Nutr. 2016;115(4):737–50.PubMedCrossRef
62.
Qin LQ, Xu JY, Han SF, Zhang ZL, Zhao YY, Szeto IM. Dairy consumption and risk of cardiovascular disease: an updated meta-analysis of prospective cohort studies. Asia Pac J Clin Nutr. 2015;24(1):90–100.PubMed
63.
•• Pimpin L, Wu JH, Haskelberg H, Del Gobbo L, Mozaffarian D. Is butter back? A systematic review and meta-analysis of butter consumption and risk of cardiovascular disease, diabetes, and total mortality. PLoS One. 2016;11(6):e0158118. A systematic review and meta-analysis focused specifically on butter. Based on a limited number of studies, butter was inversely associated with diabetes type 2, with no associations for CHD or stroke. PubMedPubMedCentralCrossRef
64.
Hu D, Huang J, Wang Y, Zhang D, Qu Y. Dairy foods and risk of stroke: a meta-analysis of prospective cohort studies. Nutr Metab Cardiovasc Dis. 2014;24(5):460–9.PubMedCrossRef
65.
Praagman J, Franco OH, Ikram MA, Soedamah-Muthu SS, Engberink MF, van Rooij FJ, et al. Dairy products and the risk of stroke and coronary heart disease: the Rotterdam study. Eur J Nutr. 2015;54(6):981–90.PubMedCrossRef
66.
Dalmeijer GW, Struijk EA, van der Schouw YT, Soedamah-Muthu SS, Verschuren WM, Boer JM, et al. Dairy intake and coronary heart disease or stroke--a population-based cohort study. Int J Cardiol. 2013;167(3):925–9.PubMedCrossRef
67.
Praagman J, Dalmeijer GW, van der Schouw YT, Soedamah-Muthu SS, Monique Verschuren WM, Bas Bueno-de-Mesquita H, et al. The relationship between fermented food intake and mortality risk in the European prospective investigation into cancer and nutrition-Netherlands cohort. Br J Nutr. 2015;113(3):498–506.PubMedCrossRef
68.
69.
70.
Parvez S, Malik KA, Ah Kang S, Kim HY. Probiotics and their fermented food products are beneficial for health. J Appl Microbiol. 2006;100(6):1171–85.PubMedCrossRef
71.
Geleijnse JM, Kok FJ, Grobbee DE. Blood pressure response to changes in sodium and potassium intake: a metaregression analysis of randomised trials. J Hum Hypertens. 2003;17(7):471–80.PubMedCrossRef
72.
van Mierlo LA, Arends LR, Streppel MT, Zeegers MP, Kok FJ, Grobbee DE, et al. Blood pressure response to calcium supplementation: a meta-analysis of randomized controlled trials. J Hum Hypertens. 2006;20(8):571–80.PubMedCrossRef
73.
•• de Oliveira Otto MC, Mozaffarian D, Kromhout D, Bertoni AG, Sibley CT, Jacobs DR Jr, et al. Dietary intake of saturated fat by food source and incident cardiovascular disease: the multi-ethnic study of atherosclerosis. Am J Clin Nutr. 2012;96(2):397–404. Using the Multi-Ethnic Study of Atherosclerosis cohort study associations of Saturated fatty (SF) intake from different food sources and the incidence of CVD events were investigated. In this prospective cohort study, a higher intake of saturated fat from dairy was associated with lower CVD risk and a higher intake of saturated fat from meat with a higher CVD risk. This study contributed to discussions on specific types of saturated fatty acids and the role of the food matrix. PubMedPubMedCentralCrossRef
74.
Liu S, van der Schouw YT, Soedamah-Muthu SS, Spijkerman AMW, Sluijs I. Intake of dietary saturated fatty acids and risk of type 2 diabetes in the European prospective investigation into Cancer and nutrition-Netherlands cohort: associations by types, sources of fatty acids and substitution by macronutrients. Eur J Nutr. 2018. https://​doi.​org/​10.​1007/​s00394-018-1630-4.
75.
• de Goede J, Geleijnse JM, Ding EL, Soedamah-Muthu SS. Effect of cheese consumption on blood lipids: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev. 2015;73(5):259–75. Based on this meta-analysis of 5 randomized controlled trials, cheese intake, compared to butter intake reduced total, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol, but had no effect on triglycerides, despite similar polyunsaturated/saturated fatty acid ratios in both foods. This study contributed to discussions on the role of the food matrix. PubMedCrossRef
76.
Rosqvist F, Smedman A, Lindmark-Mansson H, Paulsson M, Petrus P, Straniero S, et al. Potential role of milk fat globule membrane in modulating plasma lipoproteins, gene expression, and cholesterol metabolism in humans: a randomized study. Am J Clin Nutr. 2015;102(1):20–30.PubMedCrossRef
77.
Liu Q, Rossouw JE, Roberts MB, Liu S, Johnson KC, Shikany JM, et al. Theoretical effects of substituting butter with margarine on risk of cardiovascular disease. Epidemiology. 2017;28(1):145–56.PubMedPubMedCentralCrossRef
78.
Jakobsen MU, O'Reilly EJ, Heitmann BL, Pereira MA, Balter K, Fraser GE, et al. Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies. Am J Clin Nutr. 2009;89(5):1425–32.PubMedPubMedCentralCrossRef
79.
Tremblay A, Panahi S. Yogurt consumption as a signature of a healthy diet and lifestyle. J Nutr. 2017;147(7):1476S–80S.PubMedCrossRef
80.
Lamarche B, Givens DI, Soedamah-Muthu S, Krauss RM, Jakobsen MU, Bischoff-Ferrari HA, et al. Does milk consumption contribute to cardiometabolic health and overall diet quality? Can J Cardiol. 2016;32(8):1026–32.PubMedCrossRef
81.
•• Drouin-Chartier JP, Cote JA, Labonte ME, Brassard D, Tessier-Grenier M, Desroches S, et al. Comprehensive review of the impact of dairy foods and dairy fat on cardiometabolic risk. Adv Nutr. 2016;7(6):1041–51. This narrative review summarizes evidence from RCTs of dairy consumption on cardiometabolic risk factors, including lipids, blood pressure, inflammation, insulin resistance and vascular function. In general, no effects or weak evidence was reported for effects of dairy foods on cardiometabolic risk. PubMedPubMedCentralCrossRef
82.
Benatar JR, Sidhu K, Stewart RA. Effects of high and low fat dairy food on cardio-metabolic risk factors: a meta-analysis of randomized studies. PLoS One. 2013;8(10):e76480.PubMedPubMedCentralCrossRef
83.
Turner KM, Keogh JB, Clifton PM. Dairy consumption and insulin sensitivity: a systematic review of short- and long-term intervention studies. Nutr Metab Cardiovasc Dis. 2015;25(1):3–8.PubMedCrossRef
84.
Labonte ME, Couture P, Richard C, Desroches S, Lamarche B. Impact of dairy products on biomarkers of inflammation: a systematic review of randomized controlled nutritional intervention studies in overweight and obese adults. Am J Clin Nutr. 2013;97(4):706–17.PubMedCrossRef
85.
• Ding M, Huang T, Bergholdt HK, Nordestgaard BG, Ellervik C, Qi L, et al. Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study. BMJ. 2017;356:j1000. Using the CHARGE Consortium 22 studies were analysed with Mendelian randomisation methods and a meta-analyses was conducted of an additional eight published RCTs on the association of dairy consumption with systolic blood pressure. Both the Mendelian Randomisation study and meta-analysis of RCTs did not support an association between dairy consumption and systolic blood pressure. PubMedPubMedCentralCrossRef
86.
Soedamah-Muthu SS, Verberne LD, Ding EL, Engberink MF, Geleijnse JM. Dairy consumption and incidence of hypertension: a dose-response meta-analysis of prospective cohort studies. Hypertension. 2012;60(5):1131–7.PubMedCrossRef
87.
Hartwig FP, Horta BL, Smith GD, de Mola CL, Victora CG. Association of lactase persistence genotype with milk consumption, obesity and blood pressure: a Mendelian randomization study in the 1982 Pelotas (Brazil) birth cohort, with a systematic review and meta-analysis. Int J Epidemiol. 2016;45(5):1573–87.PubMedPubMedCentralCrossRef
88.
Bergholdt HK, Nordestgaard BG, Ellervik C. Milk intake is not associated with low risk of diabetes or overweight-obesity: a Mendelian randomization study in 97,811 Danish individuals. Am J Clin Nutr. 2015;102(2):487–96.PubMedCrossRef
89.
Vissers LET, van der Schouw YT, Sluijs I. Challenge in interpretation of Mendelian randomization studies using lactase persistence as instrumental variable. Eur J Clin Nutr. 2018;72(1):179–80.PubMedCrossRef
90.
Yang Q, Lin SL, Au Yeung SL, Kwok MK, Xu L, Leung GM, et al. Genetically predicted milk consumption and bone health, ischemic heart disease and type 2 diabetes: a Mendelian randomization study. Eur J Clin Nutr. 2017;71(8):1008–12.PubMedCrossRef
91.
Bergholdt HK, Nordestgaard BG, Varbo A, Ellervik C. Milk intake is not associated with ischaemic heart disease in observational or Mendelian randomization analyses in 98,529 Danish adults. Int J Epidemiol. 2015;44(2):587–603.PubMedCrossRef
92.
Lamri A, Poli A, Emery N, Bellili N, Velho G, Lantieri O, et al. The lactase persistence genotype is associated with body mass index and dairy consumption in the D.E.S.I.R. study. Metabolism. 2013;62(9):1323–9.PubMedCrossRef
93.
Mendelian Randomization of Dairy Consumption Working Group. Dairy consumption and body mass index among adults: Mendelian randomization analysis of 184802 individuals from 25 studies. Clin Chem. 2018;64(1):183–91.CrossRef
Metadata
Title
Dairy Consumption and Cardiometabolic Diseases: Systematic Review and Updated Meta-Analyses of Prospective Cohort Studies
Authors
Sabita S. Soedamah-Muthu
Janette de Goede
Publication date
01-12-2018
Publisher
Springer US
Published in
Current Nutrition Reports / Issue 4/2018
Electronic ISSN: 2161-3311
DOI
https://doi.org/10.1007/s13668-018-0253-y

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Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

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Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

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