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Keynote webinar | Spotlight on medication adherence

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Medical Oncology
Published in: Medical Oncology 4/2010

01-12-2010 | Original Paper

Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR-16 in MCF-7 cells

Authors: Jie Yang, Yunxin Cao, Jifeng Sun, Yong Zhang

Published in: Medical Oncology | Issue 4/2010

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Abstract

The medicinal properties of curcumin are well documented in Indian and Chinese systems of medicine, which refer to its wide use in the treatment of some diseases. It has shown to have anti-carcinogenic properties and is known to prevent tumor development in some cancers. In our study, we confirmed that the expression of miR-15a and miR-16 was upregulated and that of Bcl-2 was downregulated in curcumin-treated MCF-7 cells. Silencing miR-15a and miR-16 by specific inhibitors restored the expression of Bcl-2. Thus, we concluded that curcumin can reduce the expression of Bcl-2 by upregulating the expression of miR-15a and miR-16 in MCF-7 cells.
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Metadata
Title
Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR-16 in MCF-7 cells
Authors
Jie Yang
Yunxin Cao
Jifeng Sun
Yong Zhang
Publication date
01-12-2010
Publisher
Springer US
Published in
Medical Oncology / Issue 4/2010
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-009-9344-3

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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