Intracystic papillary carcinoma of the breast: one of the youngest patient in the literature

Excerpt

A 29-year-old premenouposal women presented with bloody nipple discharge and mass in her left breast. Ultrasonography showed periareolar two solid and two cyctic masses in the ductal tract. Excisional biopsy was performed. Macroscopically, the size of the cyctic lesion was 1 × 1 cm² in diameter and pathological examination showed intracystic papillary carcinoma (IPC) and intraductal carcinoma where IPC was in continuity in the 8 mm area. After excisional biopsy, left mastectomy and sentinel lymph node dissection (SLND) were performed. On pathological examination 0.5 cm residuel IPC was determined (Fig. 1). Immunohistochemical staining showed estrogen and progesteron receptor were positive Her2/neu was 2+, confirmed by the fluorosein in situ hybridization (FISH). There was no metastasis in sentinel lymph nodes. According to the TNM classification, the postoperative stage was T2N0M0 as stage IIA. After mastectomy we planned adjuvant endocrine therapy in this case. IPC is a non-invasive papillary carcinoma variant and accounts for 0.5–1% of all breast cancer. Although IPC was reported non-invasive carcinoma, generally associated with ductal carcinoma in situ (DCIS) around the main tumor or invasive carcinoma [1‐4]. Papillary carcinomas were classified as invasive and non-invasive forms. The non-invasive form was divided into the diffuse form and the localized form. We present a case of IPC accompanying intraductal carcinoma. IPC generally occurs in older women, around 60–70 years as against other breast carcinomas [5, 6]. Although IPC commonly diagnosed in older women, our case is very young woman who is one of the youngest women in the literature.

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