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Published in: Inflammopharmacology 5/2019

01-10-2019 | Review

Curcumin: a modulator of inflammatory signaling pathways in the immune system

Authors: Kolsoum Rezaie Kahkhaie, Ali Mirhosseini, Ali Aliabadi, Asadollah Mohammadi, Mohammad Javad Mousavi, Saeed Mohammadian Haftcheshmeh, Thozhukat Sathyapalan, Amirhossein Sahebkar

Published in: Inflammopharmacology | Issue 5/2019

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Abstract

Curcumin is a natural compound derived from the spice, turmeric, that has been extensively reported for its efficacy in controlling or treatment of several inflammatory diseases. There is a growing body of literature that recognizes the anti-inflammatory effects of curcumin in the immune system. On the other hand, the role of inflammatory signaling pathways has been highlighted in the pathogenesis of several inflammatory diseases, and signaling molecules involved in these pathways are considered as valuable targets for new treatment approaches. We aimed to provide a comprehensive overview of the modulatory effects of curcumin on inflammatory signaling pathways which leads to inhibition of inflammation in different types of immune cells and animal models. In this comprehensive review, we elaborate on how curcumin can effectively inhibit multiple signaling molecules involved in inflammation including NF-κB, JAKs/STATs, MAPKs, β-catenin, and Notch-1.
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Metadata
Title
Curcumin: a modulator of inflammatory signaling pathways in the immune system
Authors
Kolsoum Rezaie Kahkhaie
Ali Mirhosseini
Ali Aliabadi
Asadollah Mohammadi
Mohammad Javad Mousavi
Saeed Mohammadian Haftcheshmeh
Thozhukat Sathyapalan
Amirhossein Sahebkar
Publication date
01-10-2019
Publisher
Springer International Publishing
Published in
Inflammopharmacology / Issue 5/2019
Print ISSN: 0925-4692
Electronic ISSN: 1568-5608
DOI
https://doi.org/10.1007/s10787-019-00607-3

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