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01-02-2017 | Original Article

Antioxidant effects of curcuminoids in patients with type 2 diabetes mellitus: a randomized controlled trial

Authors: Yunes Panahi, Nahid Khalili, Ebrahim Sahebi, Soha Namazi, Maryam Saberi Karimian, Muhammed Majeed, Amirhossein Sahebkar

Published in: Inflammopharmacology | Issue 1/2017

Abstract

Background

Oxidative stress has a key role in the pathogenesis of type II diabetes mellitus (T2DM) and its vascular complications. Antioxidant therapy has been suggested as a potential approach to blunt T2DM development and progression. The aim of this study was to assess the effects of supplementation with curcuminoids, which are natural polyphenolics from turmeric, on oxidative indices in diabetic individuals.

Methods

In this randomized double-blind placebo-controlled trial, 118 subjects with T2DM were randomized to curcuminoids (1000 mg/day co-administered with piperine 10 mg/day) or matching placebo for a period of 8 weeks. Serum total antioxidant capacity, superoxide dismutase (SOD) activities and malondialdehyde (MDA) concentrations were measured at baseline and after the supplementation period.

Results

Curcuminoids supplementation caused a significant elevation in serum total antioxidant capacity (TAC) (p < 0.001) and SOD activities (p < 0.001), while serum MDA levels were significantly reduced compared with the placebo group (p < 0.001). These results remained statistically significant after adjustment for potential confounders (baseline differences in body mass index and fasting serum insulin).

Conclusion

The present results support an antioxidant effect of curcuminoids supplementation in patients with T2DM, and call for future studies to assess the impact of these antioxidant effects on the occurrence of diabetic complications and cardiovascular endpoints.

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Title: Antioxidant effects of curcuminoids in patients with type 2 diabetes mellitus: a randomized controlled trial
Authors: Yunes Panahi
Nahid Khalili
Ebrahim Sahebi
Soha Namazi
Maryam Saberi Karimian
Muhammed Majeed
Amirhossein Sahebkar
Publication date: 01-02-2017
Publisher: Springer International Publishing
Published in: Inflammopharmacology / Issue 1/2017
Print ISSN: 0925-4692
Electronic ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-016-0301-4

ACC 2024 Congress

Springer Medicine

Antioxidant effects of curcuminoids in patients with type 2 diabetes mellitus: a randomized controlled trial

Abstract

Background

Methods

Results

Conclusion

ACC 2024 Congress

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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