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01-12-2022 | COVID-19 | Research

Enigma of COVID-19: is “multisystem inflammatory syndrome in adults” (MIS-A) predictable?

Authors: Istemi Serin, Nagehan Didem Sari, Murat Gunaltili, Ayse Karakilic, Begum Gulesir, Beyza Kal Kolik, Gulnihal Cevik, Hilal Sungurlu, Melike Keskin, Muhammed Baltik, Onurhan Cakmak, Tahir Alper Cinli

Published in: BMC Infectious Diseases | Issue 1/2022

Abstract

Background

Severe inflammation and one or more extrapulmonary organ dysfunctions have been reported and this clinical picture is defined as "multisystem inflammatory syndrome in adults" (MIS-A) in severe coronavirus disease-2019 (COVID-19). We aimed to determine the effect of LDH/lymphocyte ratio (LLR) on the development of MIS-A.

Methods

The data of 2333 patients were retrospectively analyzed.

Results

MIS-A rate was found to be 9.9% and MIS-A related mortality was 35.3%. LRR level above 0.24 was found to predict MIS-A development with 70% sensitivity and 65.2% specificity. The risk of MIS-A development was found to be 3.64 times higher in those with LRR levels above 0.24 compared to those with 0.24 and below. In patients with MIS-A, LRR level above 0.32 predicts mortality with 78% sensitivity and 70% specificity.

Conclusions

Early detection of MIS-A with high sensitivity and specificity in a practical ratio is very important in terms new studies.

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Title: Enigma of COVID-19: is “multisystem inflammatory syndrome in adults” (MIS-A) predictable?
Authors: Istemi Serin
Nagehan Didem Sari
Murat Gunaltili
Ayse Karakilic
Begum Gulesir
Beyza Kal Kolik
Gulnihal Cevik
Hilal Sungurlu
Melike Keskin
Muhammed Baltik
Onurhan Cakmak
Tahir Alper Cinli
Publication date: 01-12-2022
Publisher: BioMed Central
Keywords: COVID-19
Hemophagocytic Lymphohistiocytosis
Hemophagocytic Lymphohistiocytosis
Published in: BMC Infectious Diseases / Issue 1/2022
Electronic ISSN: 1471-2334
DOI: https://doi.org/10.1186/s12879-022-07303-8

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Background

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Conclusions

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