Correlation between genotypes of F2 rs5896 (p.Thr165Met) polymorphism and urinary prothrombin fragment 1

Excerpt

Urinary prothrombin fragment 1 (UPTF1) is an F1 activation peptide of human prothrombin [1]. This 31-kDa glycoprotein, which was originally referred to as crystal matrix protein, was found to be the major protein incorporated within calcium oxalate (CaOx) crystals generated from human urine in vitro [2]. This protein is a potent inhibitor of CaOx crystal growth and aggregation in undiluted human urine and in inorganic conditions [3, 4]. A single nucleotide polymorphism (SNP) (rs5896: NM_000506.4:c.494C>T; NP_000497.1:p.Thr165Met) that is a genetic variation of F2 gene encoding human prothrombin was reported to be associated with kidney stone disease (KSD) risk in a group of female patients from Northeastern Thailand [5]. We hypothesised that this F2 variation correlates with human urinary prothrombin level. The aim of this study was to investigate the association between this genetic variation and UPTF1 protein in normal female subjects. …