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01-05-2020 | Coronavirus | Editorial

COVID-19 in the heart and the lungs: could we “Notch” the inflammatory storm?

Authors: Paola Rizzo, Francesco Vieceli Dalla Sega, Francesca Fortini, Luisa Marracino, Claudio Rapezzi, Roberto Ferrari

Published in: Basic Research in Cardiology | Issue 3/2020

Abstract

From January 2020, coronavirus disease (COVID-19) originated in China has spread around the world. The disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The presence of myocarditis, cardiac arrest, and acute heart failure in COVID-19 patients suggests the existence of a relationship between SARS-CoV-2 infection and cardiac disease. The Notch signalling is a major regulator of cardiovascular function and it is also implicated in several biological processes mediating viral infections. In this report we discuss the possibility to target Notch signalling to prevent SARS-CoV-2 infection and interfere with the progression of COVID-19- associated heart and lungs disease.

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Title: COVID-19 in the heart and the lungs: could we “Notch” the inflammatory storm?
Authors: Paola Rizzo
Francesco Vieceli Dalla Sega
Francesca Fortini
Luisa Marracino
Claudio Rapezzi
Roberto Ferrari
Publication date: 01-05-2020
Publisher: Springer Berlin Heidelberg
Keywords: Coronavirus
SARS-CoV-2
COVID-19
Cytokines
Published in: Basic Research in Cardiology / Issue 3/2020
Print ISSN: 0300-8428
Electronic ISSN: 1435-1803
DOI: https://doi.org/10.1007/s00395-020-0791-5

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