Top

Endocrine

Published in:

12-10-2023 | Coronary Heart Disease | Original Article

Fibrinogen/albumin ratio and carotid artery plaques in coronary heart disease patients with different glucose metabolic states: a RCSCD-TCM study

Authors: Xu Wang, Mengnan Huang, Zhu Li, Yijia Liu, Mei Ma, Yuanyuan He, Rongrong Yang, Lin Li, Shan Gao, Chunquan Yu

Published in: Endocrine | Issue 1/2024

Abstract

Aim

The relationship between fibrinogen/albumin ratio (FAR) and carotid artery plaques (CAPs) was investigated in patients with coronary heart disease (CHD).

Methods

A total of 11,624 patients with CHD were enrolled and divided into quartiles based on the FAR (Q1: FAR index ≤ 0.0663; Q2: 0.0664 ≤ FAR index ≤ 0.0790; Q3: 0.0791 ≤ FAR index ≤ 0.0944; Q4: FAR index > 0.0944). Patients were classified into three groups according to their blood glucose levels: normal glucose regulation (NGR), prediabetes mellitus (pre-DM), and diabetes mellitus (DM) groups. Carotid ultrasonography was performed to detect CAPs. The relationship between FAR and CAPs was evaluated using logistic and subgroup analyses.

Results

Among 11,624 participants, 8738 (75.14%) had CAPs. Compared with Q1, the odds ratio (OR) of Q4 in patients with CHD was 2.00 (95% confidence interval [CI]: 1.71–2.34) after multivariate adjustment. Taking Q1 as a reference, a higher OR was observed in Q4 of FAR for CAPs in men [OR: 2.26; 95% CI: 1.73–2.95] in the multi-adjusted models. Moreover, multivariate adjustment indicated that the highest OR was observed in patients with CHD and DM (OR: 2.36; 95% CI: 1.80–3.10).

Conclusions

A significant association between FAR and CAPs was observed in patients with CHD, regardless of sex or blood glucose levels. Therefore, FAR may be used as an effective indicator to identify patients at a high risk of CAPs among patients with CHD.

Available only for authorised users

P. Libby, Inflammation in atherosclerosis—no longer a theory. Clin. Chem. 67(1), 131–142 (2021). https://doi.org/10.1093/clinchem/hvaa275CrossRefPubMed

O.P. Akinyelure, L.D. Colantonio, N.S. Chaudhary et al. Inflammation biomarkers and incident coronary heart disease: the reasons for geographic and racial differences in stroke study. Am. Heart J. 253(undefined), 39–47 (2022). https://doi.org/10.1016/j.ahj.2022.07.001CrossRefPubMed

Y. Liu, Z. Li, X. Wang et al. Effects of adjuvant Chinese patent medicine therapy on major adverse cardiovascular events in patients with coronary heart disease angina pectoris: a population-based retrospective cohort study. Acupunct. Herb. Med 2(2), 110–118 (2022). https://doi.org/10.1097/HM9.0000000000000028CrossRef

N. Puig, P. Camps-Renom, M. Camacho et al. Plasma sICAM-1 as a biomarker of carotid plaque inflammation in patients with a recent ischemic stroke. Translational Stroke Research, 1–12 (2022). https://doi.org/10.1007/s12975-022-01002-x

W.B. Horton, E.J. Barrett, Microvascular dysfunction in diabetes mellitus and cardiometabolic disease. Endocr. Rev. 42(Jan 1), 29–55 (2021). https://doi.org/10.1210/endrev/bnaa025CrossRefPubMed

X. Cheng, Z. Li, M. Yang, Y. Liu, S. Wang et al. Association of HbA1c with carotid artery plaques in patients with coronary heart disease: a retrospective clinical study. Acta Cardiologica, 1–9 (2022). https://doi.org/10.1080/00015385.2022.2040822

C. Chen, C. Lu, W. Liu et al. Association between fibrinogen/albumin ratio and arterial stiffness in patients with type 2 diabetes: a cross-sectional study. Front. Pharmacol. 13, 1120043 (2023). https://doi.org/10.3389/fphar.2022.1120043CrossRefPubMedPubMedCentral

L. Fu, Z. Liu, Y. Liu, Fibrinogen-like protein 2 in inflammatory diseases: a future therapeutic target. Int. Immunopharmacol. 116, 109799 (2023). https://doi.org/10.1016/j.intimp.2023.109799CrossRefPubMed

C.T. Hsieh, K.L. Chien, H.C. Hsu et al. Associations between fibrinogen levels and the risk of cardiovascular disease and all-cause death: a cohort study from the Chin-Shan community in Taiwan. BMJ Open 12(4), e054638 (2022). https://doi.org/10.1136/bmjopen-2021-054638CrossRefPubMedPubMedCentral

10.

D. Yuan, P. Jiang, P. Zhu et al. Prognostic value of fibrinogen in patients with coronary artery disease and prediabetes or diabetes following percutaneous coronary intervention: 5-year findings from a large cohort study. Cardiovasc. Diabetol. 20(1), 1–13 (2021). https://doi.org/10.1186/s12933-021-01335-1CrossRef

11.

G.J. Quinlan, G.S. Martin, T.W. Evans, Albumin: biochemical properties and therapeutic potential. Hepatology 41(6), 1211–1219 (2005). https://doi.org/10.1002/hep.20720CrossRefPubMed

12.

Y.Y. Zheng, T.T. Wu, Y. Chen et al. Gamma‐glutamyl transferase to albumin ratio as a novel predictor of bleeding events and mortality in patients after percutaneous coronary intervention: a retrospective cohort study. Catheter. Cardiovasc. Interven. 95, 572–578 (2020). https://doi.org/10.1002/ccd.28696CrossRef

13.

Z. Duan, C. Luo, B. Fu et al. Association between fibrinogen-to-albumin ratio and the presence and severity of coronary artery disease in patients with acute coronary syndrome. BMC Cardiovasc. Disord. 21(1), 1–10 (2021). https://doi.org/10.1186/s12872-021-02400-zCrossRef

14.

M. Li, C. Tang, E. Luo et al. Relation of fibrinogen-to-albumin ratio to severity of coronary artery disease and long-term prognosis in patients with non-ST elevation acute coronary syndrome. BioMed Res. Int. 2020 (2020). https://doi.org/10.1155/2020/1860268

15.

B. Deveci, E. Gazi, Relation between globulin, fibrinogen, and albumin with the presence and severity of coronary artery disease. Angiology 72(2), 174–180 (2021). https://doi.org/10.1177/0003319720959985CrossRefPubMed

16.

P. Wang, D. Yuan, C. Zhang et al. High fibrinogen-to-albumin ratio with type 2 diabetes mellitus is associated with poor prognosis in patients undergoing percutaneous coronary intervention: 5-year findings from a large cohort. Cardiovasc. Diabetol. 21(1), 1–13 (2022). https://doi.org/10.1186/s12933-022-01477-wCrossRefPubMedPubMedCentral

17.

T. Corriere, S. Di Marca, E. Cataudella et al. Neutrophil-to-Lymphocyte ratio is a strong predictor of atherosclerotic carotid plaques in older adults. Nutr. Metab. Cardiovasc. Dis. 28(1), 23–27 (2018). https://doi.org/10.1016/j.numecd.2017.10.022CrossRefPubMed

18.

X. Li, J. Li, G. Wu, Relationship of neutrophil-to-lymphocyte ratio with carotid plaque vulnerability and occurrence of vulnerable carotid plaque in patients with acute ischemic stroke. BioMed Res. Int. 2021 (2021). https://doi.org/10.1155/2021/6894623

19.

C. Varım, P. Varım, B.A. Acar et al. Usefulness of the platelet-to-lymphocyte ratio in predicting the severity of carotid artery stenosis in patients undergoing carotid angiography. Kaohsiung J. Med. Sci. 32(2), 86–90 (2016). https://doi.org/10.1016/j.kjms.2015.12.007CrossRefPubMed

20.

A. Bolayir, E. Bolayir, Can lymphocyte to monocyte ratio be used as a predictor of atherosclerotic carotid plaques in elderly adults? Cumhur. Med. J. 40(2), 120–127 (2018). https://doi.org/10.7197/223.v40i37154.406575CrossRef

21.

Y. Liu, M. Ma, L. Li et al. Association between sensitivity to thyroid hormones and dyslipidemia in patients with coronary heart disease. Endocrine 79(3), 459–468 (2023). https://doi.org/10.1007/s12020-022-03254-xCrossRefPubMed

22.

S.Y. Kim, The definition of obesity[J]. Korean J. Fam. Med. 37(6), 309–309 (2016). https://doi.org/10.4082/kjfm.2016.37.6.309CrossRefPubMedPubMedCentral

23.

American Diabetes Association, Standards of medical care in diabetes–2013. Diabetes Care 36(Suppl 1), S11–S66 (2013). https://doi.org/10.2337/dc13-s011CrossRef

24.

F. Mach, C. Baigent, A.L. Catapano et al. ESC Scientific Document Group. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Atherosclerosis 290, 140–205 (2020). https://doi.org/10.1016/j.atherosclerosis.2019.08.014CrossRef

25.

B. Williams, G. Mancia, W. Spiering et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH). Eur. Heart J. 39(33), 3021–3104 (2018). https://doi.org/10.1714/3026.30245CrossRefPubMed

26.

J.H. Stein, C.E. Korcarz, R.T. Hurst et al. American Society of Echocardiography Carotid intima-media thickness task force. Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid intima-media thickness task force. Endorsed by the society for vascular medicine. J. Am. Soc. Echocardiogr. 21(2), 93–111 (2008). https://doi.org/10.1016/j.echo.2007.11.011CrossRefPubMed

27.

Z. Li, Y. He, S. Wang et al. Association between triglyceride glucose index and carotid artery plaque in different glucose metabolic states in patients with coronary heart disease: a RCSCD-TCM study in China. Cardiovasc. Diabetol. 21(1), 1–11 (2022). https://doi.org/10.1186/s12933-022-01470-3CrossRefPubMedPubMedCentral

28.

W. Zhang, L. Liu, H. Chen et al. Association between the triglyceride-glucose index and the presence and prognosis of coronary microvascular dysfunction in patients with chronic coronary syndrome. Cardiovasc. Diabetol. 22(1), 1–13 (2023). https://doi.org/10.1186/s12933-023-01846-zCrossRef

29.

L. Song, X. Zhao, R. Chen et al. Association of PCSK9 with inflammation and platelet activation markers and recurrent cardiovascular risks in STEMI patients undergoing primary PCI with or without diabetes. Cardiovasc. Diabetol. 21(1), 1–13 (2022). https://doi.org/10.1186/s12933-022-01519-3CrossRef

30.

L. Gago, M. del Mar Vila, M. Grau et al. An end-to-end framework for intima media measurement and atherosclerotic plaque detection in the carotid artery. Comput. Methods Prog. Biomed. 223, 106954 (2022). https://doi.org/10.1016/j.cmpb.2022.106954CrossRef

31.

L. Fang, F.H. Yan, C. Liu et al. Systemic inflammatory biomarkers, especially fibrinogen to albumin ratio, predict prognosis in patients with pancreatic cancer. Cancer Res. Treat.: Off. J. Korean Cancer Assoc. 53(1), 131–139 (2021). https://doi.org/10.4143/crt.2020.33CrossRef

32.

B. Li, H. Deng, B. Lei et al. The prognostic value of fibrinogen to albumin ratio in malignant tumor patients: a meta-analysis. Front. Oncol. 12. (2022). https://doi.org/10.3389/fonc.2022.985377

33.

L. Xiao, Y. Jia, X. Wang et al. The impact of preoperative fibrinogen-albumin ratio on mortality in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Clin. Chim. Acta 493, 8–13 (2019). https://doi.org/10.1016/j.cca.2019.02.018CrossRefPubMed

34.

J.J. Man, J.A. Beckman, I.Z. Jaffe, Sex as a biological variable in atherosclerosis. Circ. Res. 126(9), 1297–1319 (2020). https://doi.org/10.1161/circresaha.120.315930CrossRefPubMedPubMedCentral

35.

D.H.K. van Dam-Nolen, N.C.M. van Egmond, K. Dilba et al. Sex differences in plaque composition and morphology among symptomatic patients with mild-to-moderate carotid artery stenosis. Stroke 53(2), 370–378 (2022). https://doi.org/10.1161/strokeaha.121.036564CrossRefPubMedPubMedCentral

36.

D.H.K. van Dam-Nolen, N.C.M. van Egmond, P.J. Koudstaal et al. Sex differences in carotid atherosclerosis: a systematic review and meta-analysis. Stroke 54(2), 315–326 (2023). https://doi.org/10.1161/strokeaha.122.041046CrossRefPubMed

37.

R. Huang, Q. Dai, L. Chang et al. The association between fibrinogen-to-albumin ratio (FAR) and adverse prognosis in patients with acute decompensated heart failure at different glucose metabolic states. Cardiovasc. Diabetol. 21(1), 1–13 (2022). https://doi.org/10.1186/s12933-022-01662-xCrossRef

38.

S.T. Smiley, J.A. King, W.W. Hancock, Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J. Immunol. 167(5), 2887–2894 (2001). https://doi.org/10.4049/jimmunol.167.5.2887CrossRefPubMed

39.

C.M. Shannon, S.H. Ballew, N. Daya et al. Serum albumin and risks of hospitalization and death: findings from the atherosclerosis risk in communities study. J. Am. Geriatrics Soc. 69(10), 2865–2876 (2021). https://doi.org/10.1111/jgs.17313CrossRef

40.

E. Hasheminasabgorji, J.C. Jha, Dyslipidemia, diabetes and atherosclerosis: role of inflammation and ROS-redox-sensitive factors. Biomedicines 9(11), 1602 (2021). https://doi.org/10.3390/biomedicines9111602CrossRefPubMedPubMedCentral

41.

U.P. Gujral, R. Jagannathan, S. He et al. Association between varying cut-points of intermediate hyperglycemia and risk of mortality, cardiovascular events and chronic kidney disease: a systematic review and meta-analysis. BMJ Open Diabetes Res. Care 9(1), e001776 (2021). https://doi.org/10.1136/bmjdrc-2020-001776CrossRefPubMedPubMedCentral

Title: Fibrinogen/albumin ratio and carotid artery plaques in coronary heart disease patients with different glucose metabolic states: a RCSCD-TCM study
Authors: Xu Wang
Mengnan Huang
Zhu Li
Yijia Liu
Mei Ma
Yuanyuan He
Rongrong Yang
Lin Li
Shan Gao
Chunquan Yu
Publication date: 12-10-2023
Publisher: Springer US
Keywords: Coronary Heart Disease
Diabetes
Published in: Endocrine / Issue 1/2024
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-023-03558-6

Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin

Prof. Florian Limbourg

Prof. Anoop Chauhan

Developed by: Springer Medicine

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Aim

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2024

The impact of body mass index on operative time in transoral endoscopic thyroidectomy vestibular approach for thyroid cancer

Werner syndrome in a patient with hyperglycemia

Value of repeated US-guided fine-needle aspiration (US-FNAB) in the follow-up of benign thyroid nodules: a real-life study based on the MoCyThy (Modena’s Cytology of the Thyroid) DATABASE with a revision of the literature

Effects of eight-week regular high-intensity interval training and hemp (Cannabis sativa L.) seed on total testosterone level among sedentary young males: double-blind, randomized, controlled clinical trial

Serum sex hormones correlate with pathological features of papillary thyroid cancer

The gut microbiota, gut–brain axis, and type 2 diabetes

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

At a glance: The STEP trials