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06-03-2024 | Coronary Heart Disease

Correlation Between Blood Cadmium Levels and Platelet Characteristics, As Well As Their Impact on Susceptibility to Coronary Heart Disease: Findings from NHANES 2005–2018 Data

Authors: Jichen Ci, Yuze Zhai, Benjun Wang, Weiwei Han, Bianfang Yu, Fan An

Published in: Cardiovascular Toxicology | Issue 4/2024

Abstract

Investigating the correlation between blood cadmium levels, platelet characteristics, and susceptibility to coronary heart disease (CHD). Utilized NHANES 2005–2018 data with covariates such as age, sex, race, marital status, and socio-economic status. Blood cadmium served as the independent variable, while platelet count (PC) and mean platelet volume (MPV) were dependent variables. The average age of the participants was 68.77 ± 11.03 years, and 67.4% of them were male. The mean values for WBC, MPV, PC, and blood cadmium were 7.53 ± 3.36 × 10³ cells/µL, 11.33 ± 0.27fL, 57.61 ± 5.34 × 10³ cells/µL, and 2.58 ± 0.61 µg/L, respectively. Adjusting for other variables revealed increased MPV and PC with rising blood cadmium levels in cardiac patients, indicating a higher risk of CHD in those with elevated blood cadmium. The average age of the participants was 68.77 ± 11.03 years, and 67.4% of them were male. The mean values for WBC, MPV, PC, and blood cadmium were 7.53 ± 3.36 × 10³ cells/µL, 11.33 ± 0.27fL, 57.61 ± 5.34 × 10³ cells/µL, and 2.58 ± 0.61 µg/L, respectively. Adjusting for other variables revealed increased MPV and PC with rising blood cadmium levels in cardiac patients, indicating a higher risk of CHD in those with elevated blood cadmium. This study enhances understanding of how cadmium impacts platelet characteristics, contributing to increased CHD risk, providing insights for primary prevention strategies.

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Title: Correlation Between Blood Cadmium Levels and Platelet Characteristics, As Well As Their Impact on Susceptibility to Coronary Heart Disease: Findings from NHANES 2005–2018 Data
Authors: Jichen Ci
Yuze Zhai
Benjun Wang
Weiwei Han
Bianfang Yu
Fan An
Publication date: 06-03-2024
Publisher: Springer US
Keyword: Coronary Heart Disease
Published in: Cardiovascular Toxicology / Issue 4/2024
Print ISSN: 1530-7905
Electronic ISSN: 1559-0259
DOI: https://doi.org/10.1007/s12012-024-09840-x

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Correlation Between Blood Cadmium Levels and Platelet Characteristics, As Well As Their Impact on Susceptibility to Coronary Heart Disease: Findings from NHANES 2005–2018 Data

Abstract

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