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BMC Neurology

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Open Access 01-12-2021 | Coronary Heart Disease | Research

Anaemia and cerebrospinal fluid biomarkers of Alzheimer’s pathology in cognitively normal elders: the CABLE study

Authors: Xin-Yu Yang, Xiao-He Hou, Yan-Lin Bi, Hao Hu, Xi-Peng Cao, Lan Tan, Jiu-Long Yang, Jin-Tai Yu

Published in: BMC Neurology | Issue 1/2021

Abstract

Background

Anaemia has been reported to be associated with cognitive decline and Alzheimer’s disease (AD), but the associations between anaemia and cerebrospinal fluid (CSF) AD biomarkers are still unknown. This study aimed to investigate the associations between anaemia and CSF AD biomarkers.

Methods

Participants were included from the Chinese Alzheimer’s Biomarker and LifestylE (CABLE) study. The associations of anaemia and its severity with CSF AD biomarkers including β-amyloid 1–42 (Aβ42), total tau (t-tau) and phosphorylated tau (p-tau) were analysed by multiple linear regression models. Adjusted for age, gender, educational levels, APOE ε4 alleles, comorbidities (history of coronary heart disease, history of stroke, hypertension, diabetes mellitus, dyslipidaemia) and glomerular filtration rate.

Results

A total of 646 cognitively normal older adults, consisting of 117 anaemia patients and 529 non-anaemia individuals, were included in this study. Anaemia patients had lower levels of CSF Aβ42 than individuals without anaemia (p = 0.035). Besides, participants with more severe anaemia had lower CSF Aβ42 levels (p = 0.045). No significant association of anaemia with CSF t-tau and p-tau levels was found.

Conclusion

Cross-sectionally, anaemia was associated with lower CSF Aβ42 levels. These findings consolidated the causal close relationship between anaemia and AD.

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Title: Anaemia and cerebrospinal fluid biomarkers of Alzheimer’s pathology in cognitively normal elders: the CABLE study
Authors: Xin-Yu Yang
Xiao-He Hou
Yan-Lin Bi
Hao Hu
Xi-Peng Cao
Lan Tan
Jiu-Long Yang
Jin-Tai Yu
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Coronary Heart Disease
Alzheimer's Disease
Alzheimer's Disease
Biomarkers
Published in: BMC Neurology / Issue 1/2021
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-021-02487-z

2024 ASCO Annual Meeting

Springer Medicine

Anaemia and cerebrospinal fluid biomarkers of Alzheimer’s pathology in cognitively normal elders: the CABLE study

Abstract

Background

Methods

Results

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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