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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2007

Open Access 01-12-2007 | Review

Cord blood in regenerative medicine: do we need immune suppression?

Authors: Neil H Riordan, Kyle Chan, Annette M Marleau, Thomas E Ichim

Published in: Journal of Translational Medicine | Issue 1/2007

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Abstract

Cord blood is currently used as an alternative to bone marrow as a source of stem cells for hematopoietic reconstitution after ablation. It is also under intense preclinical investigation for a variety of indications ranging from stroke, to limb ischemia, to myocardial regeneration. A major drawback in the current use of cord blood is that substantial morbidity and mortality are associated with pre-transplant ablation of the recipient hematopoietic system. Here we raise the possibility that due to unique immunological properties of both the stem cell and non-stem cell components of cord blood, it may be possible to utilize allogeneic cells for regenerative applications without needing to fully compromise the recipient immune system. Issues raised will include: graft versus host potential, the immunogeneicity of the cord blood graft, and the parallels between cord blood transplantation and fetal to maternal trafficking. The previous use of unmatched cord blood in absence of any immune ablation, as well as potential steps for widespread clinical implementation of allogeneic cord blood grafts will also be discussed.
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Metadata
Title
Cord blood in regenerative medicine: do we need immune suppression?
Authors
Neil H Riordan
Kyle Chan
Annette M Marleau
Thomas E Ichim
Publication date
01-12-2007
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue 1/2007
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/1479-5876-5-8

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