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Indian Journal of Hematology and Blood Transfusion

Published in:

01-09-2014 | Case Report

Congenital Leukemia

Authors: Aishwarya Raj, Sewali Talukdar, Smita Das, Pabitra Kumar Gogoi, Damodar Das, Jina Bhattacharya

Published in: Indian Journal of Hematology and Blood Transfusion | Special Issue 1/2014

Abstract

Congenital leukemia is a rare but a well-documented disease in which leukemic process is detected at birth or very shortly thereafter (Philip McCoy and Roy Overton, Commun Clin Cytom 22:85–88, 1995). These leukemias represent approximately 0.8 % of all childhood leukemias. We present a case of congenital acute myeloid leukemia manifesting from the very first day of birth. Diagnosis of acute myeloid leukemia was suspected by the presence of blasts in the peripheral blood smear and was confirmed on bone marrow by flowcytometry. Karyotyping revealed Trisomy 21.

Philip McCoy J Jr, Roy Overton W (1995) Immunophenotyping of Congenital Leukemia. Cytom Commun Clin Cytom 22:85–88CrossRef

Prashad HVR, Kumar GN (2007) Congenital leukemia in a two month old boy. Internet J Pediat Neonatol 6(2):1–2

Kaneko Y, Shikano T, maseka N (1998) Clinical characteristics of infants acute leukemia 12:672–680

Perkins SL (2007) Hematopoietic system. In: Gilbert-Barness E (ed) Potter’s pathology of the fetus, infant and child. Mosby Inc, Philadelphia, pp 1453–1514

Campwell WA, Storlazzi E, Vintizileos AM (1962) Fetal neonatal leukemia. Arch Dis Child 37:93–98CrossRef

Iqbal W, Khan Fl, Muzaffar M, Khan UA, Mehmood-ur-Rehman, Khan MasoodA, Bari A (2005) Congenital Leukemia in Down Syndrome. Intern J Pathol 3(2):100–101

Prakash Kp, Rau Atk, Bhat St, Rau Ar (2008) Congenital Leukemia—A diagnostic dilemma. Indian J Med Paediatr Oncol 4:41–43

Pui CH (1995) Childhood leukemia. N Engl J Med 332:1618–1625PubMedCrossRef

Badhe PB, Sane SY (1992) Congenital leukemia-organ involvement in six autopsy cases. J Post Grad Med 38:127

10.

Natural history of transient myeloproliferative disorder clinically diagnosed in Down syndrome neonates: a report from the Children’s Oncology Group Study A2971. Blood December 22, 2011; 26: 6752–6759

11.

Tragiannidis A, Pana ZD, Papageorgiou T, Hatzipantelis E, Hatzistilianou M, Athanassiadou F (2011) Transient myeloproliferative disease in newborn with Down Syndrome treated with rasburicase for the risk of development of Tumor Lysis Syndrome. J Med Case Rep 5:407PubMedCrossRefPubMedCentral

Title: Congenital Leukemia
Authors: Aishwarya Raj
Sewali Talukdar
Smita Das
Pabitra Kumar Gogoi
Damodar Das
Jina Bhattacharya
Publication date: 01-09-2014
Publisher: Springer India
Published in: Indian Journal of Hematology and Blood Transfusion / Issue Special Issue 1/2014
Print ISSN: 0971-4502
Electronic ISSN: 0974-0449
DOI: https://doi.org/10.1007/s12288-013-0307-7

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