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Indian Journal of Hematology and Blood Transfusion

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01-09-2014 | Case Report

Variant Morphology in Multiple Myeloma

Authors: Prasad R. Koduri, Swarnalata Gowrishankar, Vijay Kumar Malladi

Published in: Indian Journal of Hematology and Blood Transfusion | Special Issue 1/2014

Abstract

A 45-year-old man presented to the clinic with the chief complaints of low back pain, marked weight loss, and pallor of 2 months duration. He was found to have severe normocytic anemia with leukoerythroblastosis. Bone marrow aspirate resulted in a dry tap. Marrow trephine biopsy showed findings initially interpreted as poorly differentiated carcinoma involving marrow. Immunohistochemistry and protein studies established a diagnosis of IgG Kappa multiple myeloma. Correlation of marrow biopsy findings with clinical, radiological and immunological data remain an essential part of the diagnostic evaluation of multiple myeloma.

Banerjee SS, Verma S, Shanks JH (2004) Morphological variants of plasma cell tumours. Histopathology 44:2–8PubMedCrossRef

Wei A, Juneja S (2002) Bone marrow histology of plasma cell neoplasms. J Clin Pathol 56:406CrossRef

Boo K, Cheng S (1992) A morphological and immunohistochemical study of plasma cell proliferative lesions. Malays J Pathol 14:45–48PubMed

Tanaka T, Ichimura K, Sata Y, Takata K, Morito T, Kondo E, Ohara N, Yanai H, Sakai M, Yoshino TS (2009) Frequent downregulation or loss of CD79a expression in plasma cell myelomas: potential clue for diagnosis. Pathol Int 59:804–808PubMedCrossRef

Sukpanichnant S, Cousar JB, Leelasiri A et al (1994) Diagnostic criteria and histologic grading in multiple myeloma: histologic and immunohistologic analysis of 176 cases with clinical correlation. Hum Pathol 25:308–318PubMedCrossRef

Title: Variant Morphology in Multiple Myeloma
Authors: Prasad R. Koduri
Swarnalata Gowrishankar
Vijay Kumar Malladi
Publication date: 01-09-2014
Publisher: Springer India
Published in: Indian Journal of Hematology and Blood Transfusion / Issue Special Issue 1/2014
Print ISSN: 0971-4502
Electronic ISSN: 0974-0449
DOI: https://doi.org/10.1007/s12288-013-0259-y

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