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Annals of Nuclear Medicine

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01-03-2022 | Computed Tomography | Original Article

Validity of the γ-Ray Evaluation with iodoamphetamine for Cerebral Blood Flow Assessment (REICA) method for quantification of cerebral blood flow including acetazolamide challenge test

Authors: Yoshiaki Miyazaki, Masashi Kameyama, Akira Nakamizo, Tomoyuki Noguchi, Nobuyuki Tabata

Published in: Annals of Nuclear Medicine | Issue 3/2022

Abstract

Objective

The γ-Ray Evaluation with iodoamphetamine for Cerebral Blood Flow Assessment (REICA) is a new method for quantifying cerebral blood flow (CBF) using single-photon emission computed tomography (SPECT) and [¹²³I]N-isopropyl-p-iodoamphetamine (¹²³I-IMP). The present study aimed to validate the REICA method using data including acetazolamide challenge test.

Methods

The REICA and Graph-Plot (GP) methods were used to calculate mean CBF (mCBF) for 92 acquisitions (rest: 57, stress: 35) and cerebrovascular reactivity (CVR) in 33 patients. To obtain stress data, 15 mg/kg of acetazolamide was injected intravenously 10 min before the administration of ¹²³I-IMP, and blood samples were collected under the same conditions as rest data. The reference standard was the Autoradiograph (ARG) method using arterial blood sampling, and the accuracy of the REICA method was analyzed by comparing it with each method.

Results

For mCBF, the correlation coefficients (r) were 0.792 for the REICA method and 0.636 for the GP method. For CVR, r values were 0.660 for the REICA method and 0.578 for the GP method. In both acquisitions, the REICA method had a stronger correlation with the ARG method than the GP method. For mCBF, there was a significant difference in the correlation coefficient between the two correlation coefficients (p < 0.01).

Conclusions

The REICA method was more accurate than the GP method in quantifying CBF and closer to the ARG method. The REICA method, which is a noninvasive method of cerebral blood flow quantification using ¹²³I-IMP, has great medical usefulness.

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Title: Validity of the γ-Ray Evaluation with iodoamphetamine for Cerebral Blood Flow Assessment (REICA) method for quantification of cerebral blood flow including acetazolamide challenge test
Authors: Yoshiaki Miyazaki
Masashi Kameyama
Akira Nakamizo
Tomoyuki Noguchi
Nobuyuki Tabata
Publication date: 01-03-2022
Publisher: Springer Singapore
Keywords: Computed Tomography
Computed Tomography
Acetazolamide
Published in: Annals of Nuclear Medicine / Issue 3/2022
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-021-01700-w

At a glance: The STEP trials

Springer Medicine

Validity of the γ-Ray Evaluation with iodoamphetamine for Cerebral Blood Flow Assessment (REICA) method for quantification of cerebral blood flow including acetazolamide challenge test

Abstract

Objective

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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