Skip to main content
Top

Open Access 03-05-2024 | Computed Tomography | Original Article

Photon-counting computed tomography for paediatric congenital heart defects yields images of high diagnostic quality with low radiation doses at both 70 kV and 90 kV

Authors: Fredrik Stålhammar, Marie-Louise Aurumskjöld, Sofie Meyer, Marie Wiklund, Pär Wingren, Petru Liuba, Erik Hedström

Published in: Pediatric Radiology

Login to get access

Abstract

Background

Photon-counting computed tomography (PCCT) is a new clinical method that may show better diagnostic quality at lower radiation doses than conventional CT.

Objective

To investigate the diagnostic quality and radiation dose of paediatric cardiovascular PCCT for diagnosis of congenital heart defects at 70 kV and 90 kV.

Materials and methods

This retrospective assessment included clinical non-gated paediatric PCCT examinations for assessment of congenital heart defects. Radiation doses were recorded, and overall and specific diagnostic quality (1–4) were scored by four paediatric radiologists. Agreement, differences, and trends were assessed by percent rater agreement, intraclass correlation, Mann–Whitney tests, and Jonckheere-Terpstra tests.

Results

Seventy children with congenital heart defects were examined at 70 kV (n = 35; age 2 days–16 years; 63% boys) or 90 kV (n = 35; age 2 days–17 years; 51% boys). All observers gave a median score of 4 (high diagnostic quality) for both 70 kV and 90 kV, with no difference in median values between tube voltages (all P > 0.06). Agreement for overall scores was 66–94% for 70 kV and 60–77% for 90 kV. Agreement for specific scores was 80–97% for 70 kV and 83–89% for 90 kV. Size-dependent dose estimate was 0.68 mGy (0.25–2.02 mGy) for 70 kV and 1.10 mGy (0.58–2.71 mGy; P < 0.001) for 90 kV. Effective dose was 0.30 mSv (0.15–0.82 mSv) for 70 kV and 0.39 mSv (0.22–1.51 mSv; P = 0.01) for 90 kV.

Conclusion

Paediatric cardiovascular PCCT yields images for congenital heart defects of high diagnostic quality with low radiation dose at both 70 kV and 90 kV.
Literature
1.
go back to reference Prakash A, Powell AJ, Geva T (2010) Multimodality noninvasive imaging for assessment of congenital heart disease. Circ Cardiovasc Imaging 3:112–125CrossRefPubMed Prakash A, Powell AJ, Geva T (2010) Multimodality noninvasive imaging for assessment of congenital heart disease. Circ Cardiovasc Imaging 3:112–125CrossRefPubMed
2.
go back to reference Han BK, Rigsby CK, Hlavacek A, Leipsic J, Nicol ED, Siegel MJ, Bardo D, Abbara S, Ghoshhajra B, Lesser JR, Raman S, Crean AM, Society of Cardiovascular Computed Tomography, Society of Pediatric Radiology, North American Society of Cardiac Imaging (2015) Computed tomography imaging in patients with congenital heart disease part I: Rationale and utility. An expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT): Endorsed by the Society of Pediatric Radiology (SPR) and the North American Society of Cardiac Imaging (NASCI). J Cardiovasc Comput Tomogr 9:475–492CrossRef Han BK, Rigsby CK, Hlavacek A, Leipsic J, Nicol ED, Siegel MJ, Bardo D, Abbara S, Ghoshhajra B, Lesser JR, Raman S, Crean AM, Society of Cardiovascular Computed Tomography, Society of Pediatric Radiology, North American Society of Cardiac Imaging (2015) Computed tomography imaging in patients with congenital heart disease part I: Rationale and utility. An expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT): Endorsed by the Society of Pediatric Radiology (SPR) and the North American Society of Cardiac Imaging (NASCI). J Cardiovasc Comput Tomogr 9:475–492CrossRef
3.
go back to reference Saengsin K, Pickard SS, Prakash A (2022) Utility of cardiac CT in infants with congenital heart disease: diagnostic performance and impact on management. J Cardiovasc Comput Tomogr 16:345–349CrossRefPubMed Saengsin K, Pickard SS, Prakash A (2022) Utility of cardiac CT in infants with congenital heart disease: diagnostic performance and impact on management. J Cardiovasc Comput Tomogr 16:345–349CrossRefPubMed
4.
go back to reference Aspelin P, Aubry P, Fransson SG, Strasser R, Willenbrock R, Berg KJ (2003) Nephrotoxicity in high-risk patients study of isoosmolar, low-osmolar non-ionic contrast media study I Nephrotoxic effects in high-risk patients undergoing angiography. N Engl J Med 348:491–499CrossRefPubMed Aspelin P, Aubry P, Fransson SG, Strasser R, Willenbrock R, Berg KJ (2003) Nephrotoxicity in high-risk patients study of isoosmolar, low-osmolar non-ionic contrast media study I Nephrotoxic effects in high-risk patients undergoing angiography. N Engl J Med 348:491–499CrossRefPubMed
5.
go back to reference Bruce RJ, Djamali A, Shinki K, Michel SJ, Fine JP, Pozniak MA (2009) Background fluctuation of kidney function versus contrast-induced nephrotoxicity. AJR Am J Roentgenol 192:711–718CrossRefPubMed Bruce RJ, Djamali A, Shinki K, Michel SJ, Fine JP, Pozniak MA (2009) Background fluctuation of kidney function versus contrast-induced nephrotoxicity. AJR Am J Roentgenol 192:711–718CrossRefPubMed
6.
go back to reference Leng S, Bruesewitz M, Tao S, Rajendran K, Halaweish AF, Campeau NG, Fletcher JG, McCollough CH (2019) Photon-counting detector CT: system design and clinical applications of an emerging technology. Radiographics 39:729–743CrossRefPubMed Leng S, Bruesewitz M, Tao S, Rajendran K, Halaweish AF, Campeau NG, Fletcher JG, McCollough CH (2019) Photon-counting detector CT: system design and clinical applications of an emerging technology. Radiographics 39:729–743CrossRefPubMed
7.
go back to reference Willemink MJ, Persson M, Pourmorteza A, Pelc NJ, Fleischmann D (2018) Photon-counting CT: technical principles and clinical prospects. Radiology 289:293–312CrossRefPubMed Willemink MJ, Persson M, Pourmorteza A, Pelc NJ, Fleischmann D (2018) Photon-counting CT: technical principles and clinical prospects. Radiology 289:293–312CrossRefPubMed
8.
go back to reference Dirrichs T, Tietz E, Ruffer A, Hanten J, Nguyen TD, Dethlefsen E, Kuhl CK (2023) Photon-counting versus dual-source CT of congenital heart defects in neonates and infants: initial experience. Radiology 307:e223088CrossRefPubMed Dirrichs T, Tietz E, Ruffer A, Hanten J, Nguyen TD, Dethlefsen E, Kuhl CK (2023) Photon-counting versus dual-source CT of congenital heart defects in neonates and infants: initial experience. Radiology 307:e223088CrossRefPubMed
9.
go back to reference Deak PD, Smal Y, Kalender WA (2010) Multisection CT protocols: sex- and age-specific conversion factors used to determine effective dose from dose-length product. Radiology 257:158–166CrossRefPubMed Deak PD, Smal Y, Kalender WA (2010) Multisection CT protocols: sex- and age-specific conversion factors used to determine effective dose from dose-length product. Radiology 257:158–166CrossRefPubMed
10.
go back to reference Gamer M, Lemon J (2019) irr: various coefficients of interrater reliability and agreement. R package version 0.84.1. IFPS Gamer M, Lemon J (2019) irr: various coefficients of interrater reliability and agreement. R package version 0.84.1. IFPS
11.
go back to reference Team RC (2023) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria Team RC (2023) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria
12.
go back to reference Jonckheere AR (1954) A distribution-free k-sample test against ordered alternatives. Biometrika 41:133–145CrossRef Jonckheere AR (1954) A distribution-free k-sample test against ordered alternatives. Biometrika 41:133–145CrossRef
13.
go back to reference Yu L, Bruesewitz MR, Vrieze TJ, McCollough CH (2019) Lead shielding in pediatric chest CT: effect of apron placement outside the scan volume on radiation dose reduction. AJR Am J Roentgenol 212:151–156CrossRefPubMed Yu L, Bruesewitz MR, Vrieze TJ, McCollough CH (2019) Lead shielding in pediatric chest CT: effect of apron placement outside the scan volume on radiation dose reduction. AJR Am J Roentgenol 212:151–156CrossRefPubMed
14.
go back to reference Kravchenko D, Hart C, Garbe S, Luetkens JA, Isaak A, Mesropyan N, Vergnat M, Leyens J, Attenberger U, Kuetting D (2022) Image quality and radiation dose of dual source high pitch computed tomography in pediatric congenital heart disease. Sci Rep 12:9934CrossRefPubMedPubMedCentral Kravchenko D, Hart C, Garbe S, Luetkens JA, Isaak A, Mesropyan N, Vergnat M, Leyens J, Attenberger U, Kuetting D (2022) Image quality and radiation dose of dual source high pitch computed tomography in pediatric congenital heart disease. Sci Rep 12:9934CrossRefPubMedPubMedCentral
15.
go back to reference Ben Saad M, Rohnean A, Sigal-Cinqualbre A, Adler G, Paul JF (2009) Evaluation of image quality and radiation dose of thoracic and coronary dual-source CT in 110 infants with congenital heart disease. Pediatr Radiol 39:668–676CrossRefPubMed Ben Saad M, Rohnean A, Sigal-Cinqualbre A, Adler G, Paul JF (2009) Evaluation of image quality and radiation dose of thoracic and coronary dual-source CT in 110 infants with congenital heart disease. Pediatr Radiol 39:668–676CrossRefPubMed
16.
go back to reference Han BK, Lindberg J, Grant K, Schwartz RS, Lesser JR (2011) Accuracy and safety of high pitch computed tomography imaging in young children with complex congenital heart disease. Am J Cardiol 107:1541–1546CrossRefPubMed Han BK, Lindberg J, Grant K, Schwartz RS, Lesser JR (2011) Accuracy and safety of high pitch computed tomography imaging in young children with complex congenital heart disease. Am J Cardiol 107:1541–1546CrossRefPubMed
17.
go back to reference Young C, Taylor AM, Owens CM (2011) Paediatric cardiac computed tomography: a review of imaging techniques and radiation dose consideration. Eur Radiol 21:518–529CrossRefPubMed Young C, Taylor AM, Owens CM (2011) Paediatric cardiac computed tomography: a review of imaging techniques and radiation dose consideration. Eur Radiol 21:518–529CrossRefPubMed
18.
go back to reference Boone J, Strauss K, Cody D, McCollough C, McNitt-Gray M, Toth T (2011) AAPM Report No. 204: Size-specific dose estimates (SSDE) in pediatric and adult body CT examinations. Am Assoc Physicists Med Boone J, Strauss K, Cody D, McCollough C, McNitt-Gray M, Toth T (2011) AAPM Report No. 204: Size-specific dose estimates (SSDE) in pediatric and adult body CT examinations. Am Assoc Physicists Med
Metadata
Title
Photon-counting computed tomography for paediatric congenital heart defects yields images of high diagnostic quality with low radiation doses at both 70 kV and 90 kV
Authors
Fredrik Stålhammar
Marie-Louise Aurumskjöld
Sofie Meyer
Marie Wiklund
Pär Wingren
Petru Liuba
Erik Hedström
Publication date
03-05-2024
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Radiology
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-024-05939-z