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01-04-2011 | Neuro

Cerebral blood volume imaging by flat detector computed tomography in comparison to conventional multislice perfusion CT

Authors: Tobias Struffert, Yu Deuerling-Zheng, Stephan Kloska, Tobias Engelhorn, Jan Boese, Michael Zellerhoff, Stefan Schwab, Arnd Doerfler

Published in: European Radiology | Issue 4/2011

Abstract

Objective

We tested the hypothesis that Flat Detector computed tomography (FD-CT) with intravenous contrast medium would allow the calculation of whole brain cerebral blood volume (CBV) mapping (FD-CBV) and would correlate with multislice Perfusion CT (PCT).

Methods

Twenty five patients were investigated with FD-CBV and PCT. Correlation of the CBV maps of both techniques was carried out with measurements from six anatomical regions from both sides of the brain. Mean values of each region and the correlation coefficient were calculated. Bland-Altman analysis was performed to compare the two different imaging techniques.

Results

The image and data quality of both PCT and FD-CBV were suitable for evaluation in all patients. The mean CBV values of FD-CBV and PCT showed only minimal differences with overlapping standard deviation. The correlation coefficient was 0.79 (p < 0.01). Bland-Altman analysis showed a mean difference of -0.077 ± 0.48 ml/100 g between FD-CBV and PCT CBV measurements, indicating that FD-CBV values were only slightly lower than those of PCT.

Conclusion

CBV mapping with intravenous contrast medium using Flat Detector CT compared favourably with multislice PCT. The ability to assess cerebral perfusion within the angiographic suite may improve the management of ischaemic stroke and evaluation of the efficacy of dedicated therapies.

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Title: Cerebral blood volume imaging by flat detector computed tomography in comparison to conventional multislice perfusion CT
Authors: Tobias Struffert
Yu Deuerling-Zheng
Stephan Kloska
Tobias Engelhorn
Jan Boese
Michael Zellerhoff
Stefan Schwab
Arnd Doerfler
Publication date: 01-04-2011
Publisher: Springer-Verlag
Published in: European Radiology / Issue 4/2011
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-010-1957-6

At a glance: The STEP trials

Springer Medicine

Cerebral blood volume imaging by flat detector computed tomography in comparison to conventional multislice perfusion CT

Abstract

Objective

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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