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Journal of Cancer Research and Clinical Oncology

Published in:

01-11-2013 | Original Paper

Comparison of metastatic lymph node ratio staging system with the 7th AJCC system for colorectal cancer

Authors: Jizhun Zhang, Liang Lv, Yingjiang Ye, Kewei Jiang, Zhanlong Shen, Shan Wang

Published in: Journal of Cancer Research and Clinical Oncology | Issue 11/2013

Abstract

Purpose

To evaluate the prognostic value and staging accuracy of the metastatic lymph node ratio (rN) staging system for colorectal cancer.

Methods

A total of 1,127 patients with colorectal cancer who underwent curative surgery between 2000 and 2011 at our institute were analyzed. Lymph nodes status was assigned according to American Joint Committee on Cancer (AJCC) pN system and rN system. Patients with colon cancer (group 1, n = 652) and rectal cancer (group 2, n = 475) were analyzed separately.

Results

The rN staging system was generated using 0.2 and 0.6 as the cutoff values of lymph node ratio and then compared with AJCC pN stages. Linear regression model revealed that the number of retrieved lymph node was related to number of metastatic lymph nodes. After a median follow-up of 46 months, the 5-year survival rates of patients with more than 12 lymph nodes (LNs) retrieved were better than cases with fewer than 12 LNs, while the differences were not obvious in rN classification.

Conclusions

The rN category is a better prognostic tool than the AJCC pN category for colorectal cancer patients after curative surgery.

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Title: Comparison of metastatic lymph node ratio staging system with the 7th AJCC system for colorectal cancer
Authors: Jizhun Zhang
Liang Lv
Yingjiang Ye
Kewei Jiang
Zhanlong Shen
Shan Wang
Publication date: 01-11-2013
Publisher: Springer Berlin Heidelberg
Published in: Journal of Cancer Research and Clinical Oncology / Issue 11/2013
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-013-1525-y

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