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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-10-2013 | Original Article

Comparison of integrated whole-body [¹¹C]choline PET/MR with PET/CT in patients with prostate cancer

Authors: Michael Souvatzoglou, Matthias Eiber, Toshiki Takei, Sebastian Fürst, Tobias Maurer, Florian Gaertner, Hans Geinitz, Alexander Drzezga, Sibylle Ziegler, Stephan G. Nekolla, Ernst J. Rummeny, Markus Schwaiger, Ambros J. Beer

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 10/2013

Abstract

Purpose

To evaluate the performance of conventional [¹¹C]choline PET/CT in comparison to that of simultaneous whole-body PET/MR.

Methods

The study population comprised 32 patients with prostate cancer who underwent a single-injection dual-imaging protocol with PET/CT and subsequent PET/MR. PET/CT scans were performed applying standard clinical protocols (5 min after injection of 793 ± 69 MBq [¹¹C]choline, 3 min per bed position, intravenous contrast agent). Subsequently (52 ± 15 min after injection) PET/MR was performed (4 min per bed position). PET images were reconstructed iteratively (OSEM 3D), scatter and attenuation correction of emission data and regional allocation of [¹¹C]choline foci were performed using CT data for PET/CT and segmented Dixon MR, T1 and T2 sequences for PET/MR. Image quality of the respective PET scans and PET alignment with the respective morphological imaging modality were compared using a four point scale (0–3). Furthermore, number, location and conspicuity of the detected lesions were evaluated. SUVs for suspicious lesions, lung, liver, spleen, vertebral bone and muscle were compared.

Results

Overall 80 lesions were scored visually in 29 of the 32 patients. There was no significant difference between the two PET scans concerning number or conspicuity of the detected lesions (p not significant). PET/MR with T1 and T2 sequences performed better than PET/CT in anatomical allocation of lesions (2.87 ± 0.3 vs. 2.72 ± 0.5; p = 0.005). The quality of PET/CT images (2.97 ± 0.2) was better than that of the respective PET scan of the PET/MR (2.69 ± 0.5; p = 0.007). Overall the maximum and mean lesional SUVs exhibited high correlations between PET/CT and PET/MR (ρ = 0.87 and ρ = 0.86, respectively; both p < 0.001).

Conclusion

Despite a substantially later imaging time-point, the performance of simultaneous PET/MR was comparable to that of PET/CT in detecting lesions with increased [¹¹C]choline uptake in patients with prostate cancer. Anatomical allocation of lesions was better with simultaneous PET/MR than with PET/CT, especially in the bone and pelvis. These promising findings suggest that [¹¹C]choline PET/MR might have a diagnostic benefit compared to PET/CT in patients with prostate cancer, and now needs to be further evaluated in prospective trials.

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Title: Comparison of integrated whole-body [11C]choline PET/MR with PET/CT in patients with prostate cancer
Authors: Michael Souvatzoglou
Matthias Eiber
Toshiki Takei
Sebastian Fürst
Tobias Maurer
Florian Gaertner
Hans Geinitz
Alexander Drzezga
Sibylle Ziegler
Stephan G. Nekolla
Ernst J. Rummeny
Markus Schwaiger
Ambros J. Beer
Publication date: 01-10-2013
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 10/2013
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-013-2467-y

At a glance: The STEP trials

Springer Medicine

Comparison of integrated whole-body [¹¹C]choline PET/MR with PET/CT in patients with prostate cancer

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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