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Published in: European Journal of Nuclear Medicine and Molecular Imaging 1/2009

01-03-2009

Combined PET/MRI: a new dimension in whole-body oncology imaging?

Authors: Gerald Antoch, Andreas Bockisch

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Special Issue 1/2009

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Abstract

Introduction

Hybrid imaging systems providing morphological and functional data in a single session have been available for oncological imaging for some time. So far, computed tomography (CT) has been the morphological method-of-choice for inclusion into these hybrid imaging systems. However, recently, research has focused on hardware-based fusion of function with magnetic resonance imaging (MRI) rather than CT.

Objectives

Now that the first head-only positron emission tomography (PET)/MRI systems have been installed and whole-body systems are to be expected in the near future, potential indications in clinical oncology have to be addressed.

Discussion

This article discusses potential indications of PET/MRI in whole-body oncology imaging. Potential advantages and disadvantages compared with currently available hybrid imaging systems will be reviewed.
Literature
1.
go back to reference Haberkorn U, Schoenberg SO. Imaging of lung cancer with CT, MRT and PET. Lung Cancer 2001;34(Suppl 3):S13–23.PubMedCrossRef Haberkorn U, Schoenberg SO. Imaging of lung cancer with CT, MRT and PET. Lung Cancer 2001;34(Suppl 3):S13–23.PubMedCrossRef
3.
go back to reference Collins CD. PET/CT in oncology: for which tumours is it the reference standard? Cancer Imaging 2007;7(Spec No A):S77–87.PubMedCrossRef Collins CD. PET/CT in oncology: for which tumours is it the reference standard? Cancer Imaging 2007;7(Spec No A):S77–87.PubMedCrossRef
4.
go back to reference Antoch G, et al. Accuracy of whole-body dual-modality fluorine-18-2-fluoro-2-deoxy-d-glucose positron emission tomography and computed tomography (FDG-PET/CT) for tumor staging in solid tumors: comparison with CT and PET. J Clin Oncol 2004;22(21):4357–68.PubMedCrossRef Antoch G, et al. Accuracy of whole-body dual-modality fluorine-18-2-fluoro-2-deoxy-d-glucose positron emission tomography and computed tomography (FDG-PET/CT) for tumor staging in solid tumors: comparison with CT and PET. J Clin Oncol 2004;22(21):4357–68.PubMedCrossRef
5.
go back to reference Freudenberg LS, et al. Value of (124)I-PET/CT in staging of patients with differentiated thyroid cancer. Eur Radiol 2004;14(11):2092–8.PubMedCrossRef Freudenberg LS, et al. Value of (124)I-PET/CT in staging of patients with differentiated thyroid cancer. Eur Radiol 2004;14(11):2092–8.PubMedCrossRef
6.
go back to reference Freudenberg LS, et al. Whole-body fluorine-18 fluordeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in staging of advanced uveal melanoma. Surv Ophthalmol 2004;49(5):537–40.PubMed Freudenberg LS, et al. Whole-body fluorine-18 fluordeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in staging of advanced uveal melanoma. Surv Ophthalmol 2004;49(5):537–40.PubMed
7.
go back to reference Bar-Shalom R, et al. Clinical performance of PET/CT in evaluation of cancer: additional value for diagnostic imaging and patient management. J Nucl Med 2003;44(8):1200–9.PubMed Bar-Shalom R, et al. Clinical performance of PET/CT in evaluation of cancer: additional value for diagnostic imaging and patient management. J Nucl Med 2003;44(8):1200–9.PubMed
8.
go back to reference Pichler BJ, Judenhofer MS, Pfannenberg C. Multimodal imaging approaches: PET/CT and PET/MRI. Handb Exp Pharmacol 2008;(185 Pt 1):109–32.CrossRef Pichler BJ, Judenhofer MS, Pfannenberg C. Multimodal imaging approaches: PET/CT and PET/MRI. Handb Exp Pharmacol 2008;(185 Pt 1):109–32.CrossRef
9.
go back to reference Pichler BJ, Judenhofer MS, Wehrl HF. PET/MRI hybrid imaging: devices and initial results. Eur Radiol 2008;18(6):1077–86.PubMedCrossRef Pichler BJ, Judenhofer MS, Wehrl HF. PET/MRI hybrid imaging: devices and initial results. Eur Radiol 2008;18(6):1077–86.PubMedCrossRef
10.
go back to reference Pichler BJ, et al. Positron emission tomography/magnetic resonance imaging: the next generation of multimodality imaging? Semin Nucl Med 2008;38(3):199–208.PubMedCrossRef Pichler BJ, et al. Positron emission tomography/magnetic resonance imaging: the next generation of multimodality imaging? Semin Nucl Med 2008;38(3):199–208.PubMedCrossRef
11.
go back to reference Pauls S, et al. Improved non-invasive T-staging in non-small cell lung cancer by integrated 18F-FDG PET/CT. Nuklearmedizin 2007;46(1):9–14. quiz N1–2.PubMed Pauls S, et al. Improved non-invasive T-staging in non-small cell lung cancer by integrated 18F-FDG PET/CT. Nuklearmedizin 2007;46(1):9–14. quiz N1–2.PubMed
12.
go back to reference Babin E, et al. PET/CT for assessing mandibular invasion by intraoral squamous cell carcinomas. Clin Otolaryngol 2008;33(1):47–51.PubMedCrossRef Babin E, et al. PET/CT for assessing mandibular invasion by intraoral squamous cell carcinomas. Clin Otolaryngol 2008;33(1):47–51.PubMedCrossRef
13.
go back to reference Veit-Haibach P, et al. Diagnostic accuracy of colorectal cancer staging with whole-body PET/CT colonography. JAMA 2006;296(21):2590–600.PubMedCrossRef Veit-Haibach P, et al. Diagnostic accuracy of colorectal cancer staging with whole-body PET/CT colonography. JAMA 2006;296(21):2590–600.PubMedCrossRef
14.
go back to reference Lee BY, et al. Various image findings of skeletal muscle metastases with clinical correlation. Skeletal Radiol 2008;37:923–8.PubMedCrossRef Lee BY, et al. Various image findings of skeletal muscle metastases with clinical correlation. Skeletal Radiol 2008;37:923–8.PubMedCrossRef
15.
16.
go back to reference Fahlbusch R, Samii A. A review of cranial imaging techniques: potential and limitations. Clin Neurosurg 2007;54:100–4.PubMed Fahlbusch R, Samii A. A review of cranial imaging techniques: potential and limitations. Clin Neurosurg 2007;54:100–4.PubMed
17.
go back to reference Van Goethem M, et al. Magnetic resonance imaging in breast cancer. Eur J Surg Oncol 2006;32(9):901–10.PubMedCrossRef Van Goethem M, et al. Magnetic resonance imaging in breast cancer. Eur J Surg Oncol 2006;32(9):901–10.PubMedCrossRef
18.
go back to reference Willatt JM, et al. MR Imaging of hepatocellular carcinoma in the cirrhotic liver: challenges and controversies. Radiology 2008;247(2):311–30.PubMedCrossRef Willatt JM, et al. MR Imaging of hepatocellular carcinoma in the cirrhotic liver: challenges and controversies. Radiology 2008;247(2):311–30.PubMedCrossRef
19.
go back to reference Ba-Ssalamah A, et al. Magnetic resonance imaging of liver malignancies. Top Magn Reson Imaging 2007;18(6):445–55.PubMedCrossRef Ba-Ssalamah A, et al. Magnetic resonance imaging of liver malignancies. Top Magn Reson Imaging 2007;18(6):445–55.PubMedCrossRef
20.
go back to reference King AD, et al. The impact of 18F-FDG PET/CT on assessment of nasopharyngeal carcinoma at diagnosis. Br J Radiol 2008;81(964):291–8.PubMedCrossRef King AD, et al. The impact of 18F-FDG PET/CT on assessment of nasopharyngeal carcinoma at diagnosis. Br J Radiol 2008;81(964):291–8.PubMedCrossRef
21.
go back to reference Heusner TA, et al. Whole-body PET/CT-mammography for staging breast cancer: initial results. Br J Radiol 2008; 81(969):743–8.PubMedCrossRef Heusner TA, et al. Whole-body PET/CT-mammography for staging breast cancer: initial results. Br J Radiol 2008; 81(969):743–8.PubMedCrossRef
22.
go back to reference Heusner TA, et al. Breast cancer staging in a single session: whole-body PET/CT mammography. J Nucl Med 2008;49:1215–2.PubMedCrossRef Heusner TA, et al. Breast cancer staging in a single session: whole-body PET/CT mammography. J Nucl Med 2008;49:1215–2.PubMedCrossRef
23.
go back to reference Maderwald S, et al. To TOF or not to TOF: strategies for non-contrast-enhanced intracranial MRA at 7 T. Magma 2008;21(1–2):159–67.PubMedCrossRef Maderwald S, et al. To TOF or not to TOF: strategies for non-contrast-enhanced intracranial MRA at 7 T. Magma 2008;21(1–2):159–67.PubMedCrossRef
24.
go back to reference Antoch G, et al. Whole-body dual-modality PET/CT and whole-body MRI for tumor staging in oncology. JAMA 2003;290(24):3199–206.PubMedCrossRef Antoch G, et al. Whole-body dual-modality PET/CT and whole-body MRI for tumor staging in oncology. JAMA 2003;290(24):3199–206.PubMedCrossRef
25.
go back to reference Schmidt GP, et al. Comparison of high resolution whole-body MRI using parallel imaging and PET-CT. First experiences with a 32-channel MRI system. Radiologe 2004;44(9):889–98.PubMedCrossRef Schmidt GP, et al. Comparison of high resolution whole-body MRI using parallel imaging and PET-CT. First experiences with a 32-channel MRI system. Radiologe 2004;44(9):889–98.PubMedCrossRef
26.
go back to reference Deslauriers J, Gregoire J. Clinical and surgical staging of non-small cell lung cancer. Chest 2000;117(4 Suppl 1):96S–103S.PubMedCrossRef Deslauriers J, Gregoire J. Clinical and surgical staging of non-small cell lung cancer. Chest 2000;117(4 Suppl 1):96S–103S.PubMedCrossRef
27.
go back to reference Staples CA, et al. Mediastinal nodes in bronchogenic carcinoma: comparison between CT and mediastinoscopy. Radiology 1988;167(2):367–72.PubMed Staples CA, et al. Mediastinal nodes in bronchogenic carcinoma: comparison between CT and mediastinoscopy. Radiology 1988;167(2):367–72.PubMed
28.
go back to reference Turkington TG, et al. Accuracy of surface fit registration for PET and MR brain images using full and incomplete brain surfaces. J Comput Assist Tomogr 1995;19(1):117–24.PubMedCrossRef Turkington TG, et al. Accuracy of surface fit registration for PET and MR brain images using full and incomplete brain surfaces. J Comput Assist Tomogr 1995;19(1):117–24.PubMedCrossRef
29.
go back to reference Barentsz JO, Futterer JJ, Takahashi S. Use of ultrasmall superparamagnetic iron oxide in lymph node MR imaging in prostate cancer patients. Eur J Radiol 2007;63(3):369–72.PubMedCrossRef Barentsz JO, Futterer JJ, Takahashi S. Use of ultrasmall superparamagnetic iron oxide in lymph node MR imaging in prostate cancer patients. Eur J Radiol 2007;63(3):369–72.PubMedCrossRef
30.
go back to reference Saksena MA, Saokar A, Harisinghani MG. Lymphotropic nanoparticle enhanced MR imaging (LNMRI) technique for lymph node imaging. Eur J Radiol 2006;58(3):367–74.PubMedCrossRef Saksena MA, Saokar A, Harisinghani MG. Lymphotropic nanoparticle enhanced MR imaging (LNMRI) technique for lymph node imaging. Eur J Radiol 2006;58(3):367–74.PubMedCrossRef
31.
go back to reference Squillaci E, et al. Staging of colon cancer: whole-body MRI vs. whole-body PET-CT-initial clinical experience. Abdom Imaging. 2008; in press. Squillaci E, et al. Staging of colon cancer: whole-body MRI vs. whole-body PET-CT-initial clinical experience. Abdom Imaging. 2008; in press.
32.
go back to reference Schmidt GP, et al. Comprehensive imaging of tumor recurrence in breast cancer patients using whole-body MRI at 1.5 and 3 T compared to FDG-PET-CT. Eur J Radiol 2008;65(1):47–58.PubMedCrossRef Schmidt GP, et al. Comprehensive imaging of tumor recurrence in breast cancer patients using whole-body MRI at 1.5 and 3 T compared to FDG-PET-CT. Eur J Radiol 2008;65(1):47–58.PubMedCrossRef
33.
go back to reference Pfannenberg C, et al. Prospective comparison of 18F-fluorodeoxyglucose positron emission tomography/computed tomography and whole-body magnetic resonance imaging in staging of advanced malignant melanoma. Eur J Cancer 2007;43(3):557–64.PubMedCrossRef Pfannenberg C, et al. Prospective comparison of 18F-fluorodeoxyglucose positron emission tomography/computed tomography and whole-body magnetic resonance imaging in staging of advanced malignant melanoma. Eur J Cancer 2007;43(3):557–64.PubMedCrossRef
34.
go back to reference Schmidt GP, et al. Screening for bone metastases: whole-body MRI using a 32-channel system versus dual-modality PET-CT. Eur Radiol 2007;17(4):939–49.PubMedCrossRef Schmidt GP, et al. Screening for bone metastases: whole-body MRI using a 32-channel system versus dual-modality PET-CT. Eur Radiol 2007;17(4):939–49.PubMedCrossRef
35.
go back to reference Eustace SJ, et al. Whole-body MR imaging. Practical issues, clinical applications, and future directions. Magn Reson Imaging Clin N Am 1999;7(2):209–36.PubMed Eustace SJ, et al. Whole-body MR imaging. Practical issues, clinical applications, and future directions. Magn Reson Imaging Clin N Am 1999;7(2):209–36.PubMed
36.
go back to reference Antoch G, et al. Assessment of liver tissue after radiofrequency ablation: findings with different imaging procedures. J Nucl Med 2005;46(3):520–5.PubMed Antoch G, et al. Assessment of liver tissue after radiofrequency ablation: findings with different imaging procedures. J Nucl Med 2005;46(3):520–5.PubMed
37.
go back to reference Kleis M, et al. Diagnostic value of PET/CT for the staging and restaging of pediatric tumors. Eur J Nucl Med Mol Imaging. 2008; in press. Kleis M, et al. Diagnostic value of PET/CT for the staging and restaging of pediatric tumors. Eur J Nucl Med Mol Imaging. 2008; in press.
Metadata
Title
Combined PET/MRI: a new dimension in whole-body oncology imaging?
Authors
Gerald Antoch
Andreas Bockisch
Publication date
01-03-2009
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue Special Issue 1/2009
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-008-0951-6

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