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Surgery Today
Published in: Surgery Today 4/2013

01-04-2013 | Original Article

Combined surgical resection and radiofrequency ablation as treatment for metastatic ocular melanoma

Authors: Elika Derek, Lea Matsuoka, Sophoclis Alexopoulos, Alexander Fedenko, Yuri Genyk, Rick Selby

Published in: Surgery Today | Issue 4/2013

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Abstract

Purpose

Ocular melanoma is a rare disease with a strong predilection for the liver. Systemic and locoregional treatments for metastatic ocular melanoma have had disappointing results, with an average survival of 5–7 months. Resection and/or radiofrequency ablation (RFA) of liver lesions were attempted to improve the patient outcomes.

Methods

Eight patients with liver metastasis from ocular melanoma underwent surgery and/or RFA at the University of Southern California, University Hospital from 1 January 2001 to 31 December 2009. Their charts were retrospectively reviewed.

Results

All patients had undergone eye enucleation as the primary treatment. Four patients had all metastatic liver lesions addressed: one patient underwent left lateral segmentectomy and three patients had combinations of left lateral segmentectomies, wedge resections and RFA of two to four lesions. Two patients underwent surgical biopsies for diagnosis, one patient was unresectable and one patient underwent RFA of a dominant lesion. The median survival was 36 months. The median survival of patients who underwent surgery alone or in conjunction with RFA to address all liver lesions was 46 months.

Conclusions

There are few reports of RFA for metastatic ocular melanoma. RFA of liver lesions in addition to resection can perhaps lead to improved survival and may play a critical role in the future management of this disease.
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Metadata
Title
Combined surgical resection and radiofrequency ablation as treatment for metastatic ocular melanoma
Authors
Elika Derek
Lea Matsuoka
Sophoclis Alexopoulos
Alexander Fedenko
Yuri Genyk
Rick Selby
Publication date
01-04-2013
Publisher
Springer Japan
Published in
Surgery Today / Issue 4/2013
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-012-0244-3

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