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Published in:

01-06-2005

Treatment of Liver Metastases From Uveal Melanoma

Authors: Michel Rivoire, MD, PhD, Laurent Kodjikian, MD, PhD, Stefano Baldo, MD, Pierre Kaemmerlen, MD, Sylvie Négrier, MD, PhD, Jean-Dominique Grange, MD

Published in: Annals of Surgical Oncology | Issue 6/2005

Abstract

Background

Uveal melanoma patients with liver metastases have a poor prognosis. The effect of screening and multimodality treatment (including surgery) should be evaluated.

Methods

A total of 602 patients treated for uveal melanoma during a 14-year period had abdominal ultrasonography screening every 6 months. Sixty-three developed liver metastases as the first extraocular metastatic site. When possible, liver surgery and intra-arterial catheter implantation were performed. The influence on survival of demographics, uveal tumor characteristics, liver metastasis presentation, and treatment was studied.

Results

The median time to liver metastasis was 29 months. Twenty-eight patients (44%) were operated on: 14 (22%) had R0 liver surgery, and 14 with diffuse liver involvement had R2 liver surgery (there were no significant surgical complications). Thirty-five patients with diffuse liver involvement received systemic chemotherapy or best supportive care only. The median overall survival was 15 months (range, 3–110 months): 25 months for the 14 patients with R0 surgery, 16 months for the 14 with R2 surgery, and 11 months for the 35 with chemotherapy or supportive care. By univariate analysis, age (≤70 years), number of metastases (≤10), and quality of operation (R0) were predictive of a better prognosis.

Conclusions

In the case of liver metastases from uveal melanoma, aggressive treatment permitting tumor eradication seems to offer a chance of long-term survival to selected patients. Nevertheless, neither ultrasound screening nor quality of operation had an effect on the outcome of most patients (78%). Better screening tests and more effective multimodality treatments are required to improve survival in uveal melanoma patients with hepatic metastases.

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Title: Treatment of Liver Metastases From Uveal Melanoma
Authors: Michel Rivoire, MD, PhD
Laurent Kodjikian, MD, PhD
Stefano Baldo, MD
Pierre Kaemmerlen, MD
Sylvie Négrier, MD, PhD
Jean-Dominique Grange, MD
Publication date: 01-06-2005
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 6/2005
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/ASO.2005.06.032

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Treatment of Liver Metastases From Uveal Melanoma

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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