Top

Published in:

01-04-2013 | Original Article

Chest-tube drainage is a sign of acute exacerbation of interstitial lung disease associated with lung cancer

Authors: Tomohiro Maniwa, Mitsuhiro Isaka, Kazuo Nakagawa, Yasuhisa Ohde, Takehiro Okumura, Masahiro Endo, Haruhiko Kondo

Published in: Surgery Today | Issue 4/2013

Abstract

Purpose

Interstitial lung disease (ILD) is associated with primary lung cancer and an increased risk of postoperative acute exacerbation (AE). Although the preoperative factors associated with AE of ILD are well described, there is little information about the postoperative factors. Thus, the present study focuses on the postoperative management of chest-tube drainage associated with AE of ILD.

Methods

We conducted a retrospective chart study of 1,309 patients with lung cancer, who underwent pulmonary resection at Shizuoka Cancer Center between September 2002 and January 2011. ILD was diagnosed by chest computed tomography (CT) findings in 95 patients. After the exclusion of 6 patients with a history of pneumonectomy, the subjects of this study were 8 patients who suffered AE after surgery (AE group) and 81 patients (non-AE group) who did not. We investigated the clinicopathological findings and postoperative management of chest-tube drainage in the two groups.

Results

The clinicopathological findings of the two groups did not differ significantly. The chest tubes could not be removed before postoperative day 5 because of pleural effusion in 5 patients (62.5 %) from the AE group and 12 patients (14.8 %) from the non-AE group (P = 0.0040).

Conclusions

The postoperative volume draining from the chest-tube is an important sign of AE of ILD.

King TE Jr. Clinical advances in the diagnosis and therapy of the interstitial lung diseases. Am J Respir Crit Care Med. 2005;172:268–79.PubMedCrossRef

Kumar P, Goldstraw P, Yamada K, Nicholson AG, Wells AU, Hansell DM, et al. Pulmonary fibrosis and lung cancer: risk and benefit analysis of pulmonary resection. J Thorac Cardiovasc Surg. 2003;125:1321–7.PubMedCrossRef

Chiyo M, Sekine Y, Iwata T, Tatsumi K, Yasufuku K, Iyoda A, et al. Impact of interstitial lung disease on surgical morbidity and mortality for lung cancer: analyses of short-term and long-term outcomes. J Thorac Cardiovasc Surg. 2003;126:1141–6.PubMedCrossRef

Shintani Y, Ohta M, Iwasaki T, Ikeda N, Tomita E, Kawahara K, et al. Predictive factors for postoperative acute exacerbation of interstitial pneumonia combined with lung cancer. Gen Thorac Cardiovasc Surg. 2010;58:182–5.PubMedCrossRef

Koizumi K, Hirata T, Hirai K, Mikami I, Okada D, Yamagishi S, et al. Surgical treatment of lung cancer combined with interstitial pneumonia: the effect of surgical approach on postoperative acute exacerbation. Ann Thorac Cardiovasc Surg. 2004;10:340–6.PubMed

Park JS, Kim HK, Kim K, Kim J, Shim YM, Choi YS. Prediction of acute pulmonary complications after resection of lung cancer in patients with preexisting interstitial lung disease. Thorac Cardiovasc Surg. 2011;59:148–52.PubMedCrossRef

Muraoka M, Tagawa T, Akamine S, Oka T, Tsuchiya T, Araki M, et al. Acute interstitial pneumonia following surgery for primary lung cancer. Eur J Cardiothorac Surg. 2006;30:657–62.PubMedCrossRef

Ito H, Nakayama H, Tsuboi M, Kameda Y, Yokose T, Hasegawa C, et al. Subpleural honeycombing on high resolution computed tomography is risk factor for fatal pneumonitis. Ann Thorac Surg. 2011;91:874–8.PubMedCrossRef

Hyzy R, Huang S, Myers J, Flaherty K, Martinez F. Acute exacerbation of idiopathic pulmonary fibrosis. Chest. 2007;132:1652–8.PubMedCrossRef

10.

Coalson JJ. The ultrastructure of human fibrosing alveolitis. Virchows Arch A Pathol Anat Histol. 1982;395:181–99.PubMedCrossRef

11.

Renzoni EA, Walsh DA, Salmon M, Wells AU, Sestini P, Nicholson AG, et al. Interstitial vascularity in fibrosing alveolitis. Am J Respir Crit Care Med. 2003;167:438–43.PubMedCrossRef

12.

Ebina M, Shimizukawa M, Shibata N, Kimura Y, Suzuki T, Endo M, et al. Heterogeneous increase in CD34-positive alveolar capillaries in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2004;169:1203–8.PubMedCrossRef

13.

Yamashita M, Iwama N, Date F, Chiba R, Ebina M, Miki H, et al. Characterization of lymphangiogenesis in various stages of idiopathic diffuse alveolar damage. Hum Pathol. 2009;40:542–51.PubMedCrossRef

14.

Yamashita M, Yamauchi K, Chiba R, Iwama N, Date F, Shibata N, et al. The definition of fibrogenic processes in fibroblastic foci of idiopathic pulmonary fibrosis based on morphometric quantification of extracellular matrices. Hum Pathol. 2009;40:1278–87.PubMedCrossRef

15.

Ebina M, Shibata N, Ohta H, Hisata S, Tamada T, Ono M, et al. The disappearance of subpleural and interlobular lymphatics in idiopathic pulmonary fibrosis. Lymphat Res Biol. 2010;8:199–207.PubMedCrossRef

16.

Blivet S, Philit F, Sab JM, Langevin B, Paret M, Guérin C, et al. Outcome of patients with idiopathic pulmonary fibrosis admitted to the ICU for respiratory failure. Chest. 2001;120:209–12.PubMedCrossRef

17.

Stern JB, Mal H, Groussard O, Brugière O, Marceau A, Jebrak G, et al. Prognosis of patients with advanced idiopathic pulmonary fibrosis requiring mechanical ventilation for acute respiratory failure. Chest. 2001;120:213–9.PubMedCrossRef

18.

Kondoh Y, Taniguchi H, Kawabata Y, Yokoi T, Suzuki K, Takagi K. Acute exacerbation in idiopathic pulmonary fibrosis. Analysis of clinical and pathologic findings in three cases. Chest 1993;103:1808–12.

19.

Nishiyama O, Shimizu M, Ito Y, Kume H, Suzuki R, Yokoi T, et al. Effect of prolonged low-dose methylprednisolone therapy in acute exacerbation of idiopathic pulmonary fibrosis. Respir Care. 2001;46:698–701.PubMed

20.

Lee HS, Lee JM, Kim MS, Kim HY, Hwangbo B, Zo JI. Low-dose steroid therapy at an early phase of postoperative acute respiratory distress syndrome. Ann Thorac Surg. 2005;79:405–10.PubMedCrossRef

Title: Chest-tube drainage is a sign of acute exacerbation of interstitial lung disease associated with lung cancer
Authors: Tomohiro Maniwa
Mitsuhiro Isaka
Kazuo Nakagawa
Yasuhisa Ohde
Takehiro Okumura
Masahiro Endo
Haruhiko Kondo
Publication date: 01-04-2013
Publisher: Springer Japan
Published in: Surgery Today / Issue 4/2013
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-012-0428-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Chest-tube drainage is a sign of acute exacerbation of interstitial lung disease associated with lung cancer

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 4/2013

Cytomegalovirus infection-associated fulminant hepatitis in an immunocompetent adult requiring emergency living-donor liver transplantation: report of a case

Combined surgical resection and radiofrequency ablation as treatment for metastatic ocular melanoma

Primary esophageal adenocarcinoma arising from heterotopic gastric mucosa: report of a case

The effectiveness and appropriate management of abdominal drains in patients undergoing elective liver resection: a retrospective analysis and prospective case series

The calcitonin levels can sometimes mislead parathyroid surgeons in patients with chronic kidney disease and renal hyperparathyroidism: report of a case

Tube cavoplasty using autologous vein grafts for resected inferior vena cava reconstruction