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Virology Journal
Published in: Virology Journal 1/2012

Open Access 01-12-2012 | Short report

Co-circulation of two genotypes of dengue virus serotype 3 in Guangzhou, China, 2009

Authors: Tao Jiang, Xue-Dong Yu, Wen-Xin Hong, Wei-Ze Zhou, Man Yu, Yong-Qiang Deng, Shun-Ya Zhu, E-De Qin, Jian Wang, Cheng-Feng Qin, Fu-Chun Zhang

Published in: Virology Journal | Issue 1/2012

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Abstract

Dengue is emerging as the most important mosquito borne viral disease in the world. In mainland China, sporadic and large outbreaks of dengue illness caused by the four serotypes of dengue virus (DENV-1 to DENV-4) have been well documented. Guangdong province is the major affected area in China, and DENV-1 has dominantly circulated in Guangdong for a long time. In this study, a family cluster of DENV-3 infection in Guangzhou was described. Three cases were diagnosed as dengue fever based on clinical manifestation, serological and RT-PCR assays. Two DENV-3 strains were isolated in C6/36 cells and the complete genome sequences were determined. Phylogenetic analysis revealed that the new DENV-3 isolates from the family cluster were grouped within genotype III. Considering the fact that several DENV-3 strains within genotype V were also identified in Guangzhou in 2009, at least two genotypes of DENV-3 co-circulated in Guangzhou. Careful investigation and virological analysis should be warranted in the future.
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Metadata
Title
Co-circulation of two genotypes of dengue virus serotype 3 in Guangzhou, China, 2009
Authors
Tao Jiang
Xue-Dong Yu
Wen-Xin Hong
Wei-Ze Zhou
Man Yu
Yong-Qiang Deng
Shun-Ya Zhu
E-De Qin
Jian Wang
Cheng-Feng Qin
Fu-Chun Zhang
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2012
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/1743-422X-9-125

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