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The Journal of Headache and Pain

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Open Access 01-12-2021 | Clonidine | Case report

Episodic headache with spontaneous hypothermia reveal Shapiro’s syndrome variant with effectiveness of clonidine therapy

Authors: Mickael Aubignat, Melissa Tir, Pierre Krystkowiak, Daniela Andriuta

Published in: The Journal of Headache and Pain | Issue 1/2021

Abstract

Background

Episodic headache with spontaneous hypothermia constitute an uncommon association and is not well recognized in the International Classification of Headache Disorders (ICHD-3). Spontaneous periodic hypothermia, also called Shapiro’s syndrome, is a rare disease characterized by hypothermia attacks associated or not with hyperhidrosis without any triggering factor.

Case presentation

We report a rare case of Shapiro’s syndrome variantrevealed by episodes of headache with spontaneous hypothermia witheffectiveness of clonidine therapy in a 76-year-old Parkinson’s disease woman.

Conclusions

In the literature, apart from Shapiro’s syndrome, headache withhypothermia seem to occur very rarely. In our case,these symptoms may be considered as a very rare non-motor fluctuation ofParkinson’s disease.

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Title: Episodic headache with spontaneous hypothermia reveal Shapiro’s syndrome variant with effectiveness of clonidine therapy
Authors: Mickael Aubignat
Melissa Tir
Pierre Krystkowiak
Daniela Andriuta
Publication date: 01-12-2021
Publisher: Springer Milan
Keywords: Clonidine
Cranial MRI
Hyperhidrosis
Parkinson's Disease
Headache
Published in: The Journal of Headache and Pain / Issue 1/2021
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1186/s10194-021-01245-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Episodic headache with spontaneous hypothermia reveal Shapiro’s syndrome variant with effectiveness of clonidine therapy

Abstract

Background

Case presentation

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusions

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