Issue 9/2020
Content (10 Articles)
Pharmacokinetics and Generic Drug Switching: A Regulator’s View
Pieter J. Glerum, Cees Neef, David M. Burger, Yang Yu, Marc Maliepaard
Comparative Clinical Pharmacokinetics and Pharmacodynamics of HIV-1 Integrase Strand Transfer Inhibitors: An Updated Review
Anthony T. Podany, Kimberly K. Scarsi, Michelle M. Pham, Courtney V. Fletcher
Pharmacokinetics, Safety, and Tolerability of Selonsertib, an Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitor, Following First-in-Human Single and Multiple Ascending Doses in Healthy Subjects
Cara H. Nelson, Kim Etchevers, Saili Yi, David Breckenridge, Mischa Hepner, Uptal Patel, John Ling, Anita Mathias
Comprehensive Parent–Metabolite PBPK/PD Modeling Insights into Nicotine Replacement Therapy Strategies
Lukas Kovar, Dominik Selzer, Hannah Britz, Neal Benowitz, Gideon St. Helen, Yvonne Kohl, Robert Bals, Thorsten Lehr
Pharmacokinetic Drug–Drug Interaction of Apalutamide, Part 1: Clinical Studies in Healthy Men and Patients with Castration-Resistant Prostate Cancer
Ignacio Duran, Joan Carles, Iurie Bulat, Peter Hellemans, Anna Mitselos, Peter Ward, James Jiao, Danielle Armas, Caly Chien
Pharmacokinetic Drug–Drug Interaction of Apalutamide, Part 2: Investigating Interaction Potential Using a Physiologically Based Pharmacokinetic Model
An Van den Bergh, Jan Snoeys, Loeckie De Zwart, Peter Ward, Angela Lopez-Gitlitz, Daniele Ouellet, Mario Monshouwer, Caly Chien
An Extension of Janmahasatian’s Fat-Free Mass Model for Universal Application Across Populations of Different Ethnicities
Jaydeep Sinha, Hesham S. Al-Sallami, Stephen B. Duffull
Population Pharmacokinetics of Ibrutinib and Its Dihydrodiol Metabolite in Patients with Lymphoid Malignancies
Fanny Gallais, Loïc Ysebaert, Fabien Despas, Sandra De Barros, Loïc Dupré, Anne Quillet-Mary, Caroline Protin, Fabienne Thomas, Lucie Obéric, Ben Allal, Etienne Chatelut, Mélanie White-Koning